Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing
NCT ID: NCT01087307
Last Updated: 2025-11-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
5326 participants
OBSERVATIONAL
2010-03-02
Brief Summary
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\- Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies. The samples will be used to determine if new tests are sufficiently valid and precise to be used in research studies and for quality control purposes.
Objectives:
\- To provide a registry of samples for test development, validation, analysis, and quality control at the National Institute of Environmental Health Sciences.
Eligibility:
\- Male and nonpregnant female volunteers at least 18 years of age.
Design:
* Samples to be collected will include blood, urine, saliva, household dust, cheek cells, hair, nasal cells, stool, nail clippings, exhaled breath condensate, or sperm.
* Specimens may be collected during a one-time sample collection, or participants may be asked to provide specimens on several occasions over a specified period, not to exceed 1 year.
* Eligible participants will be asked to come to the clinical research unit to have their blood drawn and any noninvasive samples retrieved. Prior to blood draw, researchers will administer a brief past 24-hour questionnaire for research purposes. Specimens will be collected using standard clinical protocols.
* Participants will receive monetary compensation for providing samples for this protocol.
Detailed Description
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Conditions
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Keywords
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Study Design
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OTHER
OTHER
Study Groups
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Healthy Adult Volunteer
Healthy adult volunteer
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
All participants must be non-pregnant and 18 years of age or older. No children, cognitively impaired persons, or prisoners will be enrolled.
18 Years
ALL
No
Sponsors
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National Institute of Environmental Health Sciences (NIEHS)
NIH
Responsible Party
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Principal Investigators
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Stavros Garantziotis, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Institute of Environmental Health Sciences (NIEHS)
Locations
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NIEHS, Research Triangle Park
Research Triangle Park, North Carolina, United States
Countries
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References
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Whitehead GS, Hussain S, Fannin R, Trempus CS, Innes CL, Schurman SH, Cook DN, Garantziotis S. TLR5 Activation Exacerbates Airway Inflammation in Asthma. Lung. 2020 Apr;198(2):289-298. doi: 10.1007/s00408-020-00337-2. Epub 2020 Feb 14.
Hussain S, Johnson CG, Sciurba J, Meng X, Stober VP, Liu C, Cyphert-Daly JM, Bulek K, Qian W, Solis A, Sakamachi Y, Trempus CS, Aloor JJ, Gowdy KM, Foster WM, Hollingsworth JW, Tighe RM, Li X, Fessler MB, Garantziotis S. TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. Elife. 2020 Jan 28;9:e50458. doi: 10.7554/eLife.50458.
Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS Genet. 2016 Oct 27;12(10):e1006385. doi: 10.1371/journal.pgen.1006385. eCollection 2016 Oct.
Related Links
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NIH Clinical Center Detailed Web Page
Other Identifiers
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10-E-0063
Identifier Type: -
Identifier Source: secondary_id
100063
Identifier Type: -
Identifier Source: org_study_id