Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age

NCT ID: NCT01083732

Last Updated: 2016-12-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2016-02-29

Brief Summary

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To investigate the safety and tolerability of dabigatran etexilate solution in children and to obtain preliminary pharmacokinetic/pharmacodynamic data

Detailed Description

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Purpose:

Conditions

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Venous Thromboembolism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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dabigatran etexilate

treatment with dabigatran oral solution as a single dose

Group Type EXPERIMENTAL

dabigatran etexilate

Intervention Type DRUG

Experimental dose chosen based on age and weight

Interventions

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dabigatran etexilate

Experimental dose chosen based on age and weight

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. males or females 1 to less than 12 years of age
2. objective diagnosis of primary VTE
3. completion of planned treatment course with LMWH or OAC for primary VTE
4. written informed consent by parent (legal guardian) and patient assent (if applicable)

Exclusion Criteria

1. weight less than 9 kg
2. conditions associated with increased risk of bleeding
Minimum Eligible Age

1 Year

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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Boehringer Ingelheim Investigational Site

Ottawa, Ontario, Canada

Site Status

Boehringer Ingelheim Investigational Site

Roma, , Italy

Site Status

Boehringer Ingelheim Investigational Site

Vilnius, , Lithuania

Site Status

Boehringer Ingelheim Investigational Site

Kazan', , Russia

Site Status

Boehringer Ingelheim Investigational Site

Zurich, , Switzerland

Site Status

Boehringer Ingelheim Investigational Site

Bangkok, , Thailand

Site Status

Boehringer Ingelheim Investigational Site

Khon Kaen, , Thailand

Site Status

Countries

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Austria Belgium Czechia France Hungary Latvia Netherlands Norway Slovakia Spain Ukraine Canada Italy Lithuania Russia Switzerland Thailand

Other Identifiers

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2009-013618-29

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1160.89

Identifier Type: -

Identifier Source: org_study_id