Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care Unit

NCT ID: NCT01082016

Last Updated: 2010-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2013-06-30

Brief Summary

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Sleep deprivation in healthy volunteers is associated with immune dysfunction. This adverse effect of sleep deprivation likely occurs in patients suffering from acute injury and critical illness requiring intensive care unit (ICU) admission. Studies have demonstrated that sleep in ICU patients is highly abnormal. The global hypothesis for this proposal is that a strategy to promote sleep in ICU patients will increase time in rapid eye movement (REM) and slow wave sleep (SWS). This three phase proposal examines the feasibility of a sleep promotion strategy for injured and critically ill patients in the ICU.

Phase I (Development and Training): Develop an intervention manual for sleep promotion, Sleep Enhancement Program (SEP), and train ICU staff.

Phase II (Validation and Safety): Implement SEP and test for protocol fidelity and safety.

Phase III (Efficacy): Conduct a pilot trail to determine efficacy of SEP to improve SWS in ICU patients.

Detailed Description

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Conditions

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Sleep Deprivation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Control

Monitor sleep in ICU without attempts at promotion

Group Type NO_INTERVENTION

No interventions assigned to this group

Sleep promotion

Measure sleep in ICU with sleep promotion program in effect

Group Type EXPERIMENTAL

Sleep Enhancement Program (SEP)

Intervention Type OTHER

Sleep promotion in the ICU Multifaceted tool to promote sleep in ICU patients

Interventions

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Sleep Enhancement Program (SEP)

Sleep promotion in the ICU Multifaceted tool to promote sleep in ICU patients

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Received care in ICU for at least 3 days
* Received care in ICU no longer than 14 days
* Score of 3 to 5 on the Riker Sedation-Agitation Scale (SAS)
* Age \< 55 years
* Able to tolerate PO or have gastric access present (Nasogastric/Orogastric/PEG)

Exclusion Criteria

* Pregnancy
* Incarceration
* Admission diagnosis of Closed Head Injury or Traumatic Brain Injury
* Evidence of delirium on Confusion Assessment Method (CAM-ICU) Score
* Hemodynamic Instability
* Sepsis
* Multiple Organ Dysfunction
* Acute Renal Failure
* Known history of sleep disorder
* Known Psychiatric disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Arizona Biomedical Research Commission (ABRC)

OTHER

Sponsor Role collaborator

University of Arizona

OTHER

Sponsor Role lead

Responsible Party

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University of Arizona College of Medicine

Principal Investigators

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Randall S Friese, MD

Role: PRINCIPAL_INVESTIGATOR

University of Arizona College of Medicine

Locations

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University Medical Center

Tucson, Arizona, United States

Site Status

Countries

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United States

References

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Parthasarathy S, Friese RS, Ayas NT. Biological validity to sleep measurements during critical illness. Crit Care Med. 2010 Feb;38(2):705-6. doi: 10.1097/CCM.0b013e3181cbb05f. No abstract available.

Reference Type BACKGROUND
PMID: 20083935 (View on PubMed)

Friese RS. Good night, sleep tight: the time is ripe for critical care providers to wake up and focus on sleep. Crit Care. 2008;12(3):146. doi: 10.1186/cc6884. Epub 2008 May 12.

Reference Type BACKGROUND
PMID: 18492219 (View on PubMed)

Friese RS, Diaz-Arrastia R, McBride D, Frankel H, Gentilello LM. Quantity and quality of sleep in the surgical intensive care unit: are our patients sleeping? J Trauma. 2007 Dec;63(6):1210-4. doi: 10.1097/TA.0b013e31815b83d7.

Reference Type BACKGROUND
PMID: 18212640 (View on PubMed)

Friese RS. Sleep and recovery from critical illness and injury: a review of theory, current practice, and future directions. Crit Care Med. 2008 Mar;36(3):697-705. doi: 10.1097/CCM.0B013E3181643F29.

Reference Type BACKGROUND
PMID: 18176314 (View on PubMed)

Other Identifiers

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ABRC 9-022

Identifier Type: -

Identifier Source: org_study_id