Evaluation of a Noninvasive Diabetes Screening Device in Subjects at Risk for Diabetes

NCT ID: NCT01080157

Last Updated: 2012-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

509 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this research study is to test the safety and effectiveness of the SCOUT DS in measuring the concentration of substances (advanced glycation endproducts) in the skin. These substances have been found to be in higher concentrations in people with diabetes and high blood sugar. The SCOUT DS is being developed to help doctors measure these substances in skin and possibly help doctors diagnose diabetes.

Detailed Description

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The trial will be a prospective, multi-center, paired data, cohort screening trial. Up to 960 subjects will complete the study to determine the relative accuracy of SCOUT DS compared to the FPG and HbA1c tests in screening for abnormal glucose tolerance. All methods will be compared to the 2 hour value of the OGTT. An algorithm utilizes skin optical modeling as well as the spectral and blood assay data accumulated from the initial phase of the study to produce a risk score for abnormal glucose tolerance. This algorithm and the calculation of the score will be integrated into the SCOUT DS for prospective testing. The design requires three patient visits to the clinical site and up to a total of seven measurements on the SCOUT device.

Conditions

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Diabetes

Keywords

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Diabetes Diabetes Screening Experimental Medical Device

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Volunteers 18+, at risk for diabetes

SCOUT DS measurement

Intervention Type DEVICE

Non-invasive 3-5 volar forearm scan

Interventions

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SCOUT DS measurement

Non-invasive 3-5 volar forearm scan

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age greater than or equal to 45 years; OR
2. Age 18 to 44 years and a BMI \> 25 kg/m² with one or more of the following risk factors:

* Elevated waist circumference, \> 35 inches for women and \>40 inches for men
* Habitually physically inactive (does not exercise regularly)
* Has a first-degree relative with diabetes
* African American, Latino, Native American, Asian American, Pacific Islander
* Has delivered a baby weighing \> 9 lb or diagnosed with gestational diabetes
* Hypertension (≥130/≥ 85 mmHg) or being treated for hypertension
* HDL cholesterol level \< 35 mg/dL and/or a fasting triglyceride level ≥ 250 mg/dL or being treated for dyslipidemia with medication
* Has been previously diagnosed with Polycystic Ovary Syndrome (PCOS)
* Had impaired glucose tolerance or impaired fasting glucose on previous testing within the last 3 yrs
* Conditions associated with insulin resistance such as acanthosis nigricans
* History of vascular disease including heart attack, stroke, angina, coronary heart disease, atherosclerosis, congestive heart failure or peripheral arterial disease

Exclusion Criteria

* Prior participation in VL-2701
* Receiving investigational treatments in the past 14 days
* Psychosocial issues that interfere with an ability to follow study procedures
* Conditions that cause secondary diabetes including Cushing's syndrome, acromegaly, hemochromatosis, pancreatitis, or cystic fibrosis
* Diagnosed with any type of diabetes, including type 1 or 2
* Taking glucose lowering medications
* Known to be pregnant
* Receiving dialysis or having known renal compromise
* Scars, tattoos, rashes or other disruption/discoloration on the left volar forearm.
* Recent (within past month) or current oral steroid therapy or topical steroids applied to the left forearm; inhaled steroid therapy is not excluded Current chemotherapy, or chemotherapy within the past 12 months
* Receiving medications that fluoresce
* Known to have, or at risk for, photosensitivity reactions ( e.g., sensitive to ultraviolet light, or taking medication known to cause photosensitivity)
* Prior bariatric surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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VeraLight, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John Maynard, MS

Role: STUDY_DIRECTOR

VeraLight, Inc.

Locations

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Accelovance - Huntsville

Huntsville, Alabama, United States

Site Status

Accelovance - San Diego, CA

San Diego, California, United States

Site Status

Radiant Research, Inc. - Chicago

Chicago, Illinois, United States

Site Status

Accelovance - Peoria, IL

Peoria, Illinois, United States

Site Status

Radiant Research, Inc. - Kansas City

Kansas City, Kansas, United States

Site Status

Accelovance - Rockville, MD

Rockville, Maryland, United States

Site Status

Radiant Research, Inc. - Minneapolis

Minneapolis, Minnesota, United States

Site Status

Lovelace Scientific Resources, Inc.

Albuquerque, New Mexico, United States

Site Status

Radiant Research, Inc. - Cincinnati

Cincinnati, Ohio, United States

Site Status

Juno Research, LLC

Houston, Texas, United States

Site Status

Dynamed Clinical Research, LP

Houston, Texas, United States

Site Status

Radiant Research, Inc. - San Antonio

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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VL-2712

Identifier Type: -

Identifier Source: org_study_id