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Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy

NCT ID: NCT01078831

Last Updated: 2010-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-03-31

Study Completion Date

2010-04-30

Brief Summary

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The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.

Detailed Description

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Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.

Conditions

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Acute Respiratory Distress Syndrome Acute Lung Injury (ALI)

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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ARDS / ALI patients

Bronchoscopy

Intervention Type OTHER

Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.

Interventions

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Bronchoscopy

Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ARDS/ALI patients on mechanical ventilation
* endotracheal tube size 7-9mm
* age \> 18 years
* therapeutic or diagnostic bronchoscopy requested by staff physician

Exclusion Criteria

* SpO2 \< 90%
* unstable BP
* pneumothorax
* acute cardiovascular disease
* cerebrovascular or other condition that requires stable BP and saturation
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Oslo University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Oslo University Hospital

Principal Investigators

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Helge Opdahl, MD, PhD

Role: STUDY_DIRECTOR

Oslo University Hospital - Ulleval, Norway

Ole H Skjønsberg, MD, PhD

Role: STUDY_DIRECTOR

Ullevaal University Hospital

Fredrik Borchsenius, MD

Role: STUDY_DIRECTOR

Ullevaal University Hospital

Locations

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Oslo University Hospital - Ulleval

Oslo, Oslo County, Norway

Site Status

Countries

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Norway

Other Identifiers

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REK-HO Ref 191-01055, 03052001

Identifier Type: -

Identifier Source: org_study_id