A Study of Xeloda (Capecitabine) in Breast Cancer Patients With Central Nervous System (CNS) Progression

NCT ID: NCT01077726

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

3 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2010-12-31

Brief Summary

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This single arm study will assess the efficacy of Xeloda in the treatment of brain metastases in breast cancer patients with central nervous system (CNS) progression after whole brain radiotherapy. Patients will receive xeloda 1000mg/m2 po bid on days 1-14 of each 3 week cycle. The anticipated time on study treatment is until disease progression, and the target sample size is \<100 individuals.

Detailed Description

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Conditions

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Breast Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

capecitabine [Xeloda]

Intervention Type DRUG

1000mg/m2 po bid on days 1-14 of each 3 week cycle

Interventions

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capecitabine [Xeloda]

1000mg/m2 po bid on days 1-14 of each 3 week cycle

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* female patients, \>=18 years of age;
* breast cancer;
* CNS progression after radio-surgery + whole brain radiotherapy, or whole brain radiotherapy alone;
* at least one measurable lesion;
* ECOG performance status 0-2.

Exclusion Criteria

* prior systemic treatment of brain metastases;
* prior disease progression while on Xeloda treatment;
* previous history of cancer (other than curatively treated basal and squamous cell cancer of the skin or in situ cancer of the cervix) in previous 5 years;
* clinically significant cardiovascular disease.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Angers, , France

Site Status

Arras, , France

Site Status

Béziers, , France

Site Status

Bobigny, , France

Site Status

Caen, , France

Site Status

Lille, , France

Site Status

Lyon, , France

Site Status

Narbonne, , France

Site Status

Nice, , France

Site Status

Paris, , France

Site Status

Paris, , France

Site Status

Salouël, , France

Site Status

Countries

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France

Other Identifiers

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2008-007350-35

Identifier Type: -

Identifier Source: secondary_id

ML22203

Identifier Type: -

Identifier Source: org_study_id