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Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics

NCT ID: NCT01075932

Last Updated: 2010-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2009-08-31

Brief Summary

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DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.

Detailed Description

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Conditions

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Cerebral Blood Flow Cognitive Function

Keywords

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cerebral blood flow NIRS n-3 PUFAs fish oil cognitive function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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1 g DHA-rich fish oil

1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA plus 1 g olive oil

Group Type ACTIVE_COMPARATOR

DHA-rich fish oil

Intervention Type DIETARY_SUPPLEMENT

Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.

2 g DHA-rich fish oil

2 g DHA-rich fish oil containing 900 mg DHA + 180 mg EPA

Group Type ACTIVE_COMPARATOR

DHA-rich fish oil

Intervention Type DIETARY_SUPPLEMENT

Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.

Placebo

2 g olive oil

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

2 g placebo (olive oil) taken daily for 12 weeks

Interventions

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DHA-rich fish oil

Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.

Intervention Type DIETARY_SUPPLEMENT

Placebo

2 g placebo (olive oil) taken daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male/Female
* 18-35 years
* Healthy
* No herbal supplements/prescription medications (excl. contraceptive pill)
* Non smoker
* Native English speaker

Exclusion Criteria

* consumes oily fish
* takes omega-3 supplement
* food allergies to treatment ingredients
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ginsana SA

OTHER

Sponsor Role collaborator

Northumbria University

OTHER

Sponsor Role lead

Responsible Party

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Northumbria University

Principal Investigators

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Philippa A Jackson

Role: PRINCIPAL_INVESTIGATOR

Northumbria University

Locations

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Northumbria University

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Site Status

Countries

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United Kingdom

References

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Jackson PA, Reay JL, Scholey AB, Kennedy DO. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol. 2012 Jan;89(1):183-90. doi: 10.1016/j.biopsycho.2011.10.006. Epub 2011 Oct 19.

Reference Type DERIVED
PMID: 22020134 (View on PubMed)

Related Links

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http://www.nutrition-neuroscience.co.uk/

Brain, Performance and Nutrition Research Centre, Northumbria University

Other Identifiers

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16N2

Identifier Type: -

Identifier Source: org_study_id