Cognitive and Mood Effects of Docosahexaenoic Acid (DHA)-Rich and Eicosapentaenoic Acid (EPA)-Rich Fish Oil in Healthy Young Adults

NCT ID: NCT01075919

Last Updated: 2010-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

159 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2008-12-31

Brief Summary

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To date, only a small handful of studies have assessed the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cognitive function in healthy adults. The results from these studies are mixed, and have differed greatly in terms of methodology as regards sample size, treatment formulation and duration of the intervention. In order to address these issues, the present study aims to assess the effects of two different formulations of fish oil in parallel, and at doses consistent with the current recommended daily intake of oily fish, across a range of cognitive domains. The aim of the present investigation is therefore to specifically evaluate the effects of 12 weeks supplementation of DHA-rich fish oil and EPA-rich fish oil dietary supplements on cognitive function in healthy young adults maintaining a regular diet containing oily fish not more than once a week. Self-report mood assessments will form the secondary part of this investigation.

Detailed Description

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Conditions

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Cognitive Function Mood

Keywords

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n-3 PUFAs Cognitive function Healthy young adults Fish oil Mood

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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DHA-rich fish oil

1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA

Group Type ACTIVE_COMPARATOR

n-3 PUFAs

Intervention Type DIETARY_SUPPLEMENT

1 g DHA-rich fish oil taken daily for 12 weeks

EPA-rich fish oil

1 g EPA-rich fish oil containing 300 mg EPA + 200 mg DHA

Group Type ACTIVE_COMPARATOR

n-3 PUFAs

Intervention Type DIETARY_SUPPLEMENT

1 g EPA-rich fish oil taken daily for 12 weeks

Placebo

1 g Olive oil

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

1 g olive oil taken daily for 12 weeks

Interventions

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n-3 PUFAs

1 g DHA-rich fish oil taken daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Placebo

1 g olive oil taken daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

n-3 PUFAs

1 g EPA-rich fish oil taken daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male/Female
* 18-35 years
* Healthy
* No herbal supplements/prescription medications (excl. contraceptive pill)
* Non smoker
* Native English speaker

Exclusion Criteria

* Consumes ≥ 1 portion oily fish/week
* takes omega-3 supplement
* Food allergies to treatment ingredients
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ginsana SA

OTHER

Sponsor Role collaborator

Northumbria University

OTHER

Sponsor Role lead

Responsible Party

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Northumbria University

Principal Investigators

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Philippa A Jackson

Role: PRINCIPAL_INVESTIGATOR

Northumbria University

Locations

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Northumbria University

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Site Status

Countries

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United Kingdom

Related Links

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http://www.nutrition-neuroscience.co.uk/

Brain, Performance and Nutrition Research Centre, Northumbria University

Other Identifiers

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16N1

Identifier Type: -

Identifier Source: org_study_id