Measuring Musculoskeletal Symptoms in Patients Receiving Aromatase Inhibitors

NCT ID: NCT01074320

Last Updated: 2015-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-02-28

Study Completion Date

2015-08-31

Brief Summary

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Current guidelines recommend endocrine treatment with aromatase inhibitors (AIs) in post-menopausal women with hormone receptor-positive breast cancer. Musculoskeletal symptoms are commonly reported with AI treatment,however, we do not have consistent methods to measure these symptoms prospectively. This gap in our knowledge inhibits the ability to test and develop treatments for AI-associated musculoskeletal symptoms. This pilot study will evaluate functional tests and standardized instruments for their ability to prospectively assess musculoskeletal symptoms in women being treated with AIs for breast cancer.

Detailed Description

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Specific Aims: 1) identify a core set of instruments for measuring musculoskeletal symptoms, 2) model the time course and predictors of change in musculoskeletal symptoms, 3) explore the effect of musculoskeletal symptoms on adherence to AIs in women during the first 6 months of AI treatment.

Methods: We will prospectively assess musculoskeletal symptoms due to treatment with aromatase inhibitors. Post-menopausal women beginning AI treatment for hormone responsive breast cancer will be invited to join this study.

Conditions

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Breast Cancer

Keywords

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breast cancer aromatase inhibitors musculoskeletal symptoms

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Breast cancer patients on AIs

Breast cancer patients beginning Aromatase Inhibitor therapy

Other

Intervention Type OTHER

Observational study

Interventions

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Other

Observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women with stage I - IIIa invasive breast cancer,
* Hormone-receptor positive cancer (either ER+ or PR+ or both),
* Prescribed and have agreed to take exemestane, anastrazole or letrozole,
* Have completed initial treatment of surgery, RT, and/or chemotherapy,
* Are post-menopausal,
* No previous history of aromatase inhibitor therapy for invasive breast cancer,
* Have signed the consent form.

Exclusion Criteria

* History of rheumatoid arthritis,
* Unable to read or understand English,
* History of psychiatric disability affecting informed consent or compliance with study procedures.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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HealthPartners Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Karen K Swenson, RN, PhD

Role: PRINCIPAL_INVESTIGATOR

HealthPartners Institute

Locations

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North Memorial Medical Center

Robbinsdale, Minnesota, United States

Site Status

Park Nicollet Institute

Saint Louis Park, Minnesota, United States

Site Status

Countries

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United States

References

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Swenson KK, Nissen MJ, Henly SJ, Maybon L, Pupkes J, Zwicky K, Tsai ML, Shapiro AC. Identification of tools to measure changes in musculoskeletal symptoms and physical functioning in women with breast cancer receiving aromatase inhibitors. Oncol Nurs Forum. 2013 Nov;40(6):549-57. doi: 10.1188/13.ONF.549-557.

Reference Type RESULT
PMID: 24161633 (View on PubMed)

Other Identifiers

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03918-09

Identifier Type: -

Identifier Source: org_study_id