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Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

NCT ID: NCT01070368

Last Updated: 2013-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2012-10-31

Brief Summary

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Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.

Detailed Description

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Conditions

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Wheat Allergy

Keywords

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skin test open wheat challenge

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Food challenge, skin test

Skin test by two extract commercial, and in-house extract. and open challenge with wheat (except in patient with history of wheat anaphylaxis: assume as challenge positive)

Group Type EXPERIMENTAL

Commercial extract and in-house wheat extract

Intervention Type OTHER

Patients with a history of wheat allergy underwent two skin test extracts, and open challenge with wheat. A blood test for specific IgE was performed in the same time.

Interventions

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Commercial extract and in-house wheat extract

Patients with a history of wheat allergy underwent two skin test extracts, and open challenge with wheat. A blood test for specific IgE was performed in the same time.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* A patient with the age of 1-15 year old
* A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion.
* Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012

Exclusion Criteria

* First sign and symptom happens more than 4 hours since wheat ingestion
* Have underlying disease such as heart disease, epilepsy etc.
* Have contraindication for performed skin prick test
Minimum Eligible Age

1 Year

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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nittida pannakapitak

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Pediatric department, Faculty of medicine Siriraj hospital, Mahidol university

Bangkok, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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231/2552(EC4)

Identifier Type: -

Identifier Source: org_study_id