Determining the Lymphokine Activated Killer (LAK) Cytotoxicity Present in Patients Undergoing Interleukin-2 Therapy

NCT ID: NCT01068470

Last Updated: 2014-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

11 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-11-30

Study Completion Date

2012-03-31

Brief Summary

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Therapy with Interleukin-2 stimulates lymphocytes in humans to become Lymphokine-activated Killer cells (LAK). This study will determine if these killer cells are able to kill certain standard cell-lines in the laboratory.

Detailed Description

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Blood samples will be taken from patients undergoing outpatient Interleukin-2 therapy to measure the LAK cytotoxicity at baseline, after 1 cycle of therapy and 2 months later. The LAK cytotoxicity assay will be a standard colorimetric assay that measures lactic dehydrogenase release from lysed cells.

Conditions

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Melanoma Kidney Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with melanoma or kidney cancer

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients must be undergoing Interleukin-2 therapy under the care of physicians at Loma Linda University Cancer Center
* Patients must sign and give written informed consent in accordance with institutional and federal guidelines

Exclusion Criteria

* Patients not undergoing Interleukin-2 therapy under the care of physicians at Loma Linda University Cancer Center
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Loma Linda University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Walter Quan, MD

Role: PRINCIPAL_INVESTIGATOR

Loma Linda University

Locations

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Loma Linda University Cancer Center

Beaumont, California, United States

Site Status

Countries

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United States

Other Identifiers

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59210

Identifier Type: -

Identifier Source: org_study_id

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