Phase 2b Study of ALN-RSV01 in Lung Transplant Patients Infected With Respiratory Syncytial Virus (RSV)

NCT ID: NCT01065935

Last Updated: 2018-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

87 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2012-05-31

Brief Summary

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To evaluate the efficacy and safety of ALN-RSV01 plus standard of care in RSV infected lung transplant patients

Detailed Description

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Conditions

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Respiratory Syncytial Virus Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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ALN-RSV01

Group Type ACTIVE_COMPARATOR

ALN-RSV01

Intervention Type DRUG

Administered by nebulization once daily for 5 days

Normal saline

Group Type PLACEBO_COMPARATOR

Normal Saline

Intervention Type DRUG

Administered by nebulization once daily for 5 days

Interventions

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ALN-RSV01

Administered by nebulization once daily for 5 days

Intervention Type DRUG

Normal Saline

Administered by nebulization once daily for 5 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Single or bilateral lung transplant recipients
* Confirmed RSV infection
* Greater than 90 days post current lung transplant
* Rejection free for a minimum of 30 days

Exclusion Criteria

* Known viral, bacterial, or fungal respiratory co-infection at the time of RSV diagnosis
* Bronchiolitis obliterans syndrome (BOS) Grade 3 or any BOS with FEV1 that has not been stable for at least 3 months
* Use of alemtuzumab within 9 months prior to screening, anti-thymocyte globulin (ATG) within 90 days of screening or prednisone or equivalent as maintenance therapy
* Active treatment for acute graft rejection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alnylam Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Martin Zamora, MD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Denver

Alan Glanville, MB BS MD Syd, FRACP

Role: PRINCIPAL_INVESTIGATOR

St. Vincents Hospital NSW W Australia

Jens T Gottlieb, MD

Role: PRINCIPAL_INVESTIGATOR

Hannover Medical School

Locations

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Clinical Site

Phoenix, Arizona, United States

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Los Angeles, California, United States

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Denver, Colorado, United States

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Tampa, Florida, United States

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Atlanta, Georgia, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Boston, Massachusetts, United States

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Boston, Massachusetts, United States

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Ann Arbor, Michigan, United States

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St Louis, Missouri, United States

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New York, New York, United States

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Cleveland, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Darlinghurst, New South Wales, Australia

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Adelaide, South Australia, Australia

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Melbourne, Victoria, Australia

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Perth, Western Australia, Australia

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Vienna, , Austria

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Edmonton, Alberta, Canada

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Toronto, Ontario, Canada

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Paris, , France

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Strasbourg, , France

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Berlin, , Germany

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Essen, , Germany

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Hamburg, , Germany

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Hanover, , Germany

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Homburg/Saar, , Germany

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Leipzig, , Germany

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Countries

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United States Australia Austria Canada France Germany

Other Identifiers

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ALN-RSV01-109

Identifier Type: -

Identifier Source: org_study_id

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