Liver Regeneration Therapy by Intrahepatic Arterial Administration of Autologous Adipose Tissue Derived Stromal Cells

NCT ID: NCT01062750

Last Updated: 2015-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2015-05-31

Brief Summary

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Mesenchymal stem cells have capability to differentiate into hepatocyte and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cell compared to bone marrow tissue. In this trial, eligible liver cirrhosis patients will receive autologous adipose tissue derived stromal cells through intrahepatic arterial catheterization.

Detailed Description

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The population of the liver cirrhosis patients is enormous in Japan and the only radical treatment for them is liver transplantation: however, the number of giving donor is extremely limited. Mesenchymal stem cells have been capable to differentiate into mesodermal-lineage cells as well as endodermal-lineage cells such as hepatocytes. They reside in the mesenchymal tissues such as bone marrows as well as adipose tissues. The latter tissues are relatively enriched with mesenchymal stem cells compared to bone marrow cells. In this study, the cirrhotic patients will undergo intrahepatic arterial administration of autologous adipose tissue derived stromal cells through catheter.

Conditions

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Liver Cirrhosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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adipose tissue derived stromal cells

Group Type OTHER

adipose tissue derived stromal cells dosage

Intervention Type BIOLOGICAL

single administration of autologous adipose tissue derived stroma cells via intrahepatic arterial catheterization

Interventions

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adipose tissue derived stromal cells dosage

single administration of autologous adipose tissue derived stroma cells via intrahepatic arterial catheterization

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

Criteria defined in the implementation protocol
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kanazawa University

OTHER

Sponsor Role lead

Responsible Party

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Shuichi Kaneko

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Shuichi Kaneko, M.D.

Role: STUDY_CHAIR

Kanazawa University

Locations

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Kanazawa University Hospital

Kanazawa, Ishikawa-ken, Japan

Site Status

Countries

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Japan

Other Identifiers

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1132

Identifier Type: -

Identifier Source: org_study_id

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