Systems of Support (SOS) to Increase Colon Cancer Screening and Follow-up Supplement

NCT ID: NCT01052922

Last Updated: 2017-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

2260 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2011-12-31

Brief Summary

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Ancillary Aim #1 We will evaluate intervention effects by comparing binary outcomes for screening (yes/no) in the primary SOS study. In this aim, we propose to calculate actual screening rates by use of time-to-event analyses (also known as survival analysis). The outcome variable of interest is the first time since randomization to have CRCS, either based on FOBT, FS, or CS. Knowing screening rates will not only enable us to make comparisons between groups, but also over time.

Ancillary Aims #2 and #3 We will recruit additional participants for two ancillary study aims. First, we will enroll patients age 50-74 years using the same criteria as for the primary SOS study, which includes neither history of colorectal cancer nor evidence of life-limiting disease. Participants who return the questionnaire, consent and considered eligible will be randomized to receive one of three different at-home fecal test kits. The kits will be returned to the GH centralized laboratory, and participants will be informed about lab results using standard GH pathways. Participants who have a test-positive will receive a series of two follow-up surveys (first at 1-2 weeks post result and second at 4-months post result). A comparison group of test-negative results will be matched based on selected criteria, and this group will also receive the follow-up surveys. Participants at both time intervals who do not return the survey via mail will be called and if available, administered the questionnaire via phone.

Detailed Description

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Conditions

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Colorectal Cancer Screening

Keywords

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Colorectal Neoplasms Mass Screening Population Surveillance Randomized controlled trial Occult Blood Colonoscopy Sigmoidoscopy Health Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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2 sample InSure

Group Type ACTIVE_COMPARATOR

2 sample InSure

Intervention Type OTHER

Participants will be mailed to a 2 sample InSure FOBT kit to complete at home and mail back to the lab for screening.

1 sample OC-Micron

Group Type ACTIVE_COMPARATOR

1 sample OC-Micron

Intervention Type OTHER

Participants will be mailed to a 1 sample OC-MICRON FOBT kit to complete at home and mail back to the lab for screening.

3 sample g-SENSA

Group Type ACTIVE_COMPARATOR

3 sample g-SENSA

Intervention Type OTHER

Participants will be mailed to a 3 sample g-SENSA FOBT kit to complete at home and mail back to the lab for screening.

Interventions

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3 sample g-SENSA

Participants will be mailed to a 3 sample g-SENSA FOBT kit to complete at home and mail back to the lab for screening.

Intervention Type OTHER

2 sample InSure

Participants will be mailed to a 2 sample InSure FOBT kit to complete at home and mail back to the lab for screening.

Intervention Type OTHER

1 sample OC-Micron

Participants will be mailed to a 1 sample OC-MICRON FOBT kit to complete at home and mail back to the lab for screening.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Not up to date on CRCS
* Continuously enrolled in GHC for 24 months
* Expected to continue to be enrolled at GHC for 24 months

Exclusion Criteria

* Known high risk for CRC
* History of CRC
* History of inflammatory bowel disease
* Current anticoagulation therapy
* Organ failure
* Serious illness
* Debilitating disease
* Dementia
* Nursing home resident.
Minimum Eligible Age

50 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fred Hutchinson Cancer Center

OTHER

Sponsor Role collaborator

University of Washington

OTHER

Sponsor Role collaborator

Kaiser Permanente

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Beverly B Green, MD,MPH

Role: PRINCIPAL_INVESTIGATOR

Kaiser Permanente

Locations

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Kaiser Permanente Washinton Health Research Institute

Seattle, Washington, United States

Site Status

Countries

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United States

References

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Chubak J, Bogart A, Fuller S, Laing SS, Green BB. Uptake and positive predictive value of fecal occult blood tests: A randomized controlled trial. Prev Med. 2013 Nov;57(5):671-8. doi: 10.1016/j.ypmed.2013.08.032. Epub 2013 Sep 9.

Reference Type DERIVED
PMID: 24029556 (View on PubMed)

Other Identifiers

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3R01CA121125-03S1

Identifier Type: NIH

Identifier Source: org_study_id

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