Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2013-12-31

Brief Summary

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The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in AA is responsible for ethnic differences in insulin sensitivity and hypertension in AA and EA, as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D.

Acronyms: African American (AA), European American (EA), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).

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Detailed Description

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Conditions

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Insulin Sensitivity Flow-mediated Dilation Arterial Stiffness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy adolescents

Healthy adolescent African American and Caucasian females, ages 14-18

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* African American or Caucasian ethnicity
* Ages 14-18 yrs
* Healthy

Exclusion Criteria

* BMI-for age and -sex higher than 95th centile on the Centers for Disease Control and Prevention Growth Charts
* Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
* Pregnancy
* Diabetes or any chronic diseases

Minimum Eligible Age

14 Years

Maximum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes