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Nicardipine Versus Labetalol During Intubation

NCT ID: NCT01041066

Last Updated: 2009-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Brief Summary

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The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Detailed Description

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Conditions

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Patients Who Are Intubated for General Anesthesia Endotracheal Intubation

Keywords

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patients who are intubated for general anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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group L

0.4 mg/kg labetalol

Group Type ACTIVE_COMPARATOR

labetalol

Intervention Type DRUG

0.4 mg/kg labetalol intravenously 4 min before intubation

group N

20 ㎍/kg nicardipine

Group Type ACTIVE_COMPARATOR

nicardipine

Intervention Type DRUG

20 ㎍/kg nicardipine intravenously 4 min before intubation

Interventions

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labetalol

0.4 mg/kg labetalol intravenously 4 min before intubation

Intervention Type DRUG

nicardipine

20 ㎍/kg nicardipine intravenously 4 min before intubation

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria

* Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (\< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Seoul National University Bundang Hospital

Locations

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Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Jung-Hee Ryu, Ph.D

Role: CONTACT

Phone: 82-31-787-7497

Email: [email protected]

Facility Contacts

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Jung-Hee Ryu, Ph.D

Role: primary

References

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Ryu JH, Apfel CC, Whelan R, Jeon YT, Hwang JW, Do SH, Ro YJ, Kim CS. Comparative prophylactic and therapeutic effects of intravenous labetalol 0.4 mg/kg and nicardipine 20 mug/kg on hypertensive responses to endotracheal intubation in patients undergoing elective surgeries with general anesthesia: a prospective, randomized, double-blind study. Clin Ther. 2012 Mar;34(3):593-604. doi: 10.1016/j.clinthera.2012.01.017. Epub 2012 Feb 24.

Reference Type DERIVED
PMID: 22364823 (View on PubMed)

Other Identifiers

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nicardipine-labetalol

Identifier Type: -

Identifier Source: org_study_id