Feasibility Study of a Dose Increase by a Boost of Curietherapy in Pulse Dose Rate (PDR) Associated With the Extern Radiotherapy in Prostate Cancer

NCT ID: NCT01039038

Last Updated: 2011-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-11-30

Brief Summary

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The objective of the trial is to evaluating the feasibility of dose increase by a boost of curietherapy in PDR (at least 40 Gy on D95) associated to extern radiotherapy (34 Gy) in intermediate risk in prostate cancer.

Detailed Description

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Conditions

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Prostate Cancer With Intermediate Risk

Keywords

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prostate curietherapy radiotherapy intermediate risk

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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curietherapy and radiotherapy

boost of curietherapy(40 Gy)and external radiotherapy (34 Gy)

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 50 years and ≤ 75 years
* Life expectancy \>10 years
* Localized prostatic adenocarcinoma and histologically proven
* Intermediate risk cancer(T2b or PSA between 10 and 20 or Gleason = 7(3+4) according to Amico criteria
* Metastasis or pelvic pathologic ganglion (≥ 10 mm) absence
* OMS \< 2
* No previous treatment by radiotherapy and/or curietherapy
* Hormonotherapy authorized before and during the study
* Rectal or uretero-vesical pathology
* Signed informed consent
* Social security system affiliation
* Individual deprived of liberty or placed under the authority of a tutor.
* No anesthesia contraindication

Exclusion Criteria

* Adenocarcinoma not histologically proven
* Metastases presence
* Pathological nodes presence(≥ 10 mm)
* Prior prostate endoscopic resection
* history of other malignancy except for appropriately treated superficial basal cell skin cancer
* Medical contraindications to anesthesia
* Patients with uncontrolled psychiatric disease or medical disease incompatible with the protocol
* Impossibility to respect the medical follow-up of the protocol for geographical, social or psychic reasons
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Centre Francois Baclesse

OTHER

Sponsor Role lead

Responsible Party

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Centre François Baclesse

Locations

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Centre François Baclesse

Caen, Basse-normandie, France

Site Status

Countries

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France

Other Identifiers

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CURIEBOOST

Identifier Type: -

Identifier Source: org_study_id