The Physiological Response to Routine Head and Neck Cancer Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-05-31

Study Completion Date

2012-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main objective of this pilot study is to observe and document the range of changes in the blood concentrations of certain hormones, inflammatory chemicals and immune chemicals in response to the stimulus of Head and Neck cancer

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Pilot Study of Induction Chemotherapy Followed by Surgery for Locally Advanced Resectable Head and Neck Cancer

NCT01111942

Head and Neck Cancer

TERMINATED EARLY_PHASE1

H&N Cancer; Survivorship and Late Effects

NCT04758026

Head and Neck Neoplasms Survivorship

COMPLETED

Reconstructive Surgery For Head And Neck Cancer Patients

NCT00578032

Advanced Stage Head and Neck Cancer

COMPLETED

Evaluation of the Implementation of Personalised Follow-up in Head and Neck Cancer

NCT06170203

Head and Neck Cancer

RECRUITING

Patient Evaluation for Head and Neck Surgery Branch Studies

NCT00011492

Head and Neck Neoplasms Pharyngeal Cancer Oral Cancer +2 more

TERMINATED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This project is in keeping with the strategy of the anaesthetic and intensive care departments to push towards greater understanding of the immune, metabolic and inflammatory changes associated with surgery and how these may be modified through use of different anaesthetic and intensive care techniques. Through increased understanding of the stress, inflammatory and immune responses to surgery we may be able to modulate peri-operative care to reduce cytotoxic(Natural Killer and Cytotoxic T cell) immunosuppression and hence micrometastatic spread at the time of surgery in future studies.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Head and Neck Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Elective unilateral neck dissections (Levels I-V) and/or Hemithyroidectomy surgery.
* Royal Marsden Hospital patients with head and neck cancer - all histological sub-types.
* Capable of providing informed consent
* Age \>17
* American Society of Anaesthesiologists Classification I-III.

Exclusion Criteria

* Past history of ipsilateral neck dissection.
* Bilateral neck dissection
* A recent course of systemic steroids (\< 3 months)
* Pregnancy
* Involvement in drug trials
* On following medications: Interleukins, Interferons, Immunosuppressants and long term opiates
* Recent Synacthen Test (within 48 hours)
* Emergency surgery
* American Society of Anaesthesiologists Classification IV-V.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No