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Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans

NCT ID: NCT01024634

Last Updated: 2012-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

91 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians.

Detailed Description

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African-Americans are at greater risk than Caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. This is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity of resistance arteries in African-Americans. In addition, African-Americans have higher levels of inflammatory markers, and a greater sympathoexcitatory response to various stressors. This imbalance between sympathetic and reduced parasympathetic activation may directly affect vascular function and potentiate a greater inflammatory response, further altering key structural and functional properties of the vascular wall. The overall aim of this proposal is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians. We will examine these effects at rest and following a high intensity (maximal cycle ergometry) sympathoexcitation at both pre- and post-intervention time points, since sympathoexcitation may elucidate changes not evident at rest. Because African-Americans have higher levels of arterial stiffness, lower microvascular reactivity, greater responses to sympathoexcitation, greater levels of inflammatory markers and greater vasoconstrictive tone, we hypothesize that African-Americans will show differential responses to exercise training and benefit more compared to a matched group of Caucasians.

Conditions

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Vascular Health Autonomic Function

Keywords

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Arterial stiffness Endothelial function Autonomic function Inflammation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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African American Group

A group of young African American males and females

Group Type OTHER

Endurance Exercise

Intervention Type BEHAVIORAL

8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

Caucasian Group

a group of young Caucasian men and women

Group Type OTHER

Endurance Exercise

Intervention Type BEHAVIORAL

8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

Interventions

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Endurance Exercise

8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded

Exclusion Criteria

* Subjects who smoke, are severely obese (body mass index \> 35 kg/m2), or who have hypertension (blood pressure \>140/90mmHg), diabetes (fasting glucose \>110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

University of Illinois at Urbana-Champaign

OTHER

Sponsor Role lead

Responsible Party

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Bo Fernhall

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bo Fernhall, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Illinois at Urbana-Champaign

Locations

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Kinesiology and Community Health Department, University of Illinois at Urbana-Champaign

Urbana, Illinois, United States

Site Status

Countries

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United States

References

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Maroco JL, Lane AD, Ranadive SM, Yan H, Baynard T, Fernhall B. Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular-Vascular Coupling and Wasted Pressure Effort. J Am Heart Assoc. 2024 Nov 5;13(21):e036107. doi: 10.1161/JAHA.124.036107. Epub 2024 Nov 4.

Reference Type DERIVED
PMID: 39494565 (View on PubMed)

Other Identifiers

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1R01HL093249-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

UIUC 09599

Identifier Type: -

Identifier Source: org_study_id