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Role of Angiotensin II in Insulin-induced Microvascular Activity

NCT ID: NCT01024543

Last Updated: 2009-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2009-11-30

Brief Summary

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In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?

Detailed Description

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Conditions

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Insulin Sensitivity Microcirculation

Keywords

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Angiotensin II

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Placebo

Group Type SHAM_COMPARATOR

Placebo

Intervention Type DRUG

Angiotensin II

Angiotensin II

Group Type EXPERIMENTAL

Angiotensin II

Intervention Type DRUG

Angiotensin II

Phenylephrine

Phenylephrine

Group Type ACTIVE_COMPARATOR

Phenylephrine

Intervention Type DRUG

Phenylephrine

Interventions

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Angiotensin II

Angiotensin II

Intervention Type DRUG

Phenylephrine

Phenylephrine

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1.18-60 years 2.Caucasian 3.Blood pressure \<140/90 mmHg.

Exclusion Criteria

1. Obesity (BMI\>27kg/m2)
2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
4. Smoking
5. Alcohol use \>4U/day
6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
7. Pregnancy
8. Wearing contact lenses
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Maastricht University Medical Centre

Principal Investigators

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CDA Stehouwer, Prof

Role: STUDY_CHAIR

Maastricht University Medical Centre

Locations

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Maastricht University Medical Centre

Maastricht, P.o. Box 5800, Netherlands, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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MEC 06-2-074

Identifier Type: -

Identifier Source: org_study_id