Vitamin D Replacement: The Effect on Statin-Related Myalgias

NCT ID: NCT01022398

Last Updated: 2013-05-20

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2011-06-30

Brief Summary

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The purpose of this project is to determine if Vitamin D supplementation \[10,000 international units of cholecalciferol (vitamin D3) by mouth weekly\] will decrease the rate of discontinuation of statin therapy due to muscle ache/pain and decrease the occurrence of muscle ache/pain due to statin therapy.

Detailed Description

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Conditions

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HMG-CoA Reductase Inhibitors-related Myalgias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Vitamin D

Subjects will receive Vitamin D supplementation 10,000 international units of cholecalciferol (vitamin D3) by mouth weekly

Group Type EXPERIMENTAL

cholecalciferol/placebo

Intervention Type DRUG

10,000 IU by mouth weekly for 6 months

Placebo

Subjects will receive placebo (an exact replica of the vitamin D capsule that does not contain any medically active substance) by mouth weekly

Group Type PLACEBO_COMPARATOR

cholecalciferol/placebo

Intervention Type DRUG

10,000 IU by mouth weekly for 6 months

Interventions

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cholecalciferol/placebo

10,000 IU by mouth weekly for 6 months

Intervention Type DRUG

Other Intervention Names

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Vitamin D3/placebo

Eligibility Criteria

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Inclusion Criteria

* Patients who recently prescribed statins (in the last seven days) or who have had a recent increase in statin dose (in the last seven days)
* Patients aged 19-89 years old
* Men and women (not of childbearing potential)
* Patients receiving statins with concomitant ezetimibe

Exclusion Criteria

* history of alcoholism or malnutrition
* receiving concomitant niacin, fibric acid derivatives, bile acid sequestrants, or other drugs that affect cholesterol levels
Minimum Eligible Age

19 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Creighton University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Susan Schima, MD

Role: PRINCIPAL_INVESTIGATOR

Creighton University

Locations

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The Cardiac Center at Creighton University

Omaha, Nebraska, United States

Site Status

Countries

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United States

Other Identifiers

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09-15532

Identifier Type: -

Identifier Source: org_study_id

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