A Study of Taspoglutide in Patients With Inadequately Controlled Diabetes Mellitus Type 2 and Cardiovascular Disease

NCT ID: NCT01018173

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2118 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2011-01-31

Brief Summary

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This randomized, double-blind, placebo-controlled parallel arm study will assess efficacy and safety and the effects of taspoglutide on cardiovascular events in patients with inadequately controlled type 2 diabetes mellitus and established cardiovascular disease. Patients will be randomized to receive either taspoglutide subcutaneously (sc) 10mg weekly for 4 weeks followed by 20mg sc weekly, or weekly sc placebo, in addition to background anti-hyperglycemic medication and standard of care treatment for cardiovascular disease. Anticipated time on study treatment is up to 2 years. Target sample size is 2000 patients.

Detailed Description

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Conditions

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Diabetes Mellitus Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

sc weekly

taspoglutide

Group Type EXPERIMENTAL

taspoglutide

Intervention Type DRUG

10 mg sc weekly for 4 weeks, followed by 20 mg sc weekly

Interventions

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placebo

sc weekly

Intervention Type DRUG

taspoglutide

10 mg sc weekly for 4 weeks, followed by 20 mg sc weekly

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>18 years of age
* diabetes mellitus type 2
* HbA1c \>/=6.5% and \</=10% at screening
* BMI \>/=23kg/m2
* cardiovascular disease with onset \>/=1 month prior to screening

Exclusion Criteria

* diagnosis or history of type 1 diabetes or secondary forms of diabetes
* acute metabolic diabetic complications within past 6 months
* severe hypoglycemia \</=1 month prior to screening
* clinically significant gastrointestinal disease
* history of chronic or acute pancreatitis
* current New York Heart Association (NYHA) class IV heart failure or post-transplantation cardiomyopathy
* severely impaired renal function
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Buena Park, California, United States

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Calabasas, California, United States

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Fresno, California, United States

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Santa Ana, California, United States

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Walnut Creek, California, United States

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Centennial, Colorado, United States

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Colorado Springs, Colorado, United States

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Trumbull, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Clearwater, Florida, United States

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Delray Beach, Florida, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Ponte Verde, Florida, United States

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Bloomingdale, Illinois, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Evansville, Indiana, United States

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Baltimore, Maryland, United States

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Oxon Hill, Maryland, United States

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Jackson, Mississippi, United States

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St Louis, Missouri, United States

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North Platte, Nebraska, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Nashua, New Hampshire, United States

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Toms River, New Jersey, United States

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Mineola, New York, United States

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New York, New York, United States

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Calabash, North Carolina, United States

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Cary, North Carolina, United States

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Chapel Hill, North Carolina, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Mooresville, North Carolina, United States

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Raleigh, North Carolina, United States

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Bismarck, North Dakota, United States

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Bismarck, North Dakota, United States

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Cleveland, Ohio, United States

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Kettering, Ohio, United States

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Toledo, Ohio, United States

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Bend, Oregon, United States

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Medford, Oregon, United States

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Portland, Oregon, United States

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Beaver, Pennsylvania, United States

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Levittown, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pottstown, Pennsylvania, United States

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Greer, South Carolina, United States

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Hickory Grove, South Carolina, United States

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Bristol, Tennessee, United States

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Johnson City, Tennessee, United States

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Austin, Texas, United States

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Carrollton, Texas, United States

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Dallas, Texas, United States

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Dallas, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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Irving, Texas, United States

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North Richland Hills, Texas, United States

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Richardson, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Temple, Texas, United States

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Salt Lake City, Utah, United States

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Burke, Virginia, United States

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Hampton, Virginia, United States

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Manassas, Virginia, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Winchester, Virginia, United States

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Tacoma, Washington, United States

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Freemantle, Queensland, Australia

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Herston, Queensland, Australia

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Elizabeth Vale, South Australia, Australia

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Melbourne, Victoria, Australia

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Fortaleza, Ceará, Brazil

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Fortaleza, Ceará, Brazil

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Campina Grande do Sul, Paraná, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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São Paulo, São Paulo, Brazil

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São Paulo, São Paulo, Brazil

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São Paulo, São Paulo, Brazil

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São Paulo, São Paulo, Brazil

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São Paulo, São Paulo, Brazil

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Byala, , Bulgaria

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Pleven, , Bulgaria

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Plovdiv, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Varna, , Bulgaria

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Barrie, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Sherbrooke, Quebec, Canada

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Havířov, , Czechia

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Jindřichův Hradec, , Czechia

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Mariánské Lázně, , Czechia

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Olomouc, , Czechia

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Pardubice, , Czechia

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Prague, , Czechia

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Rakovník, , Czechia

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Ricany U Prahy, , Czechia

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Semily, , Czechia

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Trutnov, , Czechia

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Uherské Hradiště, , Czechia

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Ústí nad Labem, , Czechia

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Aalborg, , Denmark

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Ballerup Municipality, , Denmark

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Hvidovre, , Denmark

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Vejle, , Denmark

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Paide, , Estonia

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Saku, , Estonia

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Tallinn, , Estonia

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Tallinn, , Estonia

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Tallinn, , Estonia

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Tallinn, , Estonia

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Tartu, , Estonia

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Tartu, , Estonia

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Viljandimaa, , Estonia

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Võru, , Estonia

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Bad Lauterberg im Harz, , Germany

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Bad Oeynhausen, , Germany

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Bochum, , Germany

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Dortmund, , Germany

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Dresden, , Germany

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Essen, , Germany

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Hamburg, , Germany

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Kleve, , Germany

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Neuss, , Germany

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Nuremberg, , Germany

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Wuppertal, , Germany

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Balatonfüred, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Debrecen, , Hungary

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Gyula, , Hungary

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Hódmezővásárhely, , Hungary

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Komárom, , Hungary

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Makó, , Hungary

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Sopron, , Hungary

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Szikszó, , Hungary

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Úrhida, , Hungary

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Veszprém, , Hungary

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Ahmedabad, , India

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Aurangabad, , India

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Bangalore, , India

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Bangalore, , India

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Bangalore, , India

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Bangalore, , India

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Banglore, , India

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Bhopal, , India

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Chennai, , India

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Chennai, , India

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Chennai, , India

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Hyderabad, , India

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Jaipur, , India

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Kochi, , India

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Kolkata, , India

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Madurai, , India

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Mangalore, , India

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Mumbai, , India

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Mumbai, , India

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Nagpur, , India

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Nagpur, , India

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Pune, , India

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Pune, , India

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Pune, , India

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Jerusalem, , Israel

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Alytus, , Lithuania

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Kaunas, , Lithuania

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Kaunas, , Lithuania

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Kaunas, , Lithuania

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Kaunas, , Lithuania

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Klaipėda, , Lithuania

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Panevezys, , Lithuania

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Vilnius, , Lithuania

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Vilnius, , Lithuania

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George Town, , Malaysia

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Johor Bahru, , Malaysia

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Kelantan, , Malaysia

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Aguascalientes, , Mexico

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Chihuahua City, , Mexico

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Cuernavaca, , Mexico

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Culiacán, , Mexico

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Durango, , Mexico

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Juarez, Distrito Federal, , Mexico

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Mexico City, , Mexico

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México, , Mexico

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Monterrey, , Mexico

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Tampico, , Mexico

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Gdansk, , Poland

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Gdynia, , Poland

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Kamieniec Ząbkowicki, , Poland

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Katowice, , Poland

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Kielce, , Poland

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Krakow, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Poznan, , Poland

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Płock, , Poland

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Radom, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Bacau, , Romania

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Baia Mare, , Romania

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Bucharest, , Romania

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Bucharest, , Romania

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Bucharest, , Romania

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Bucharest, , Romania

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Constanța, , Romania

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Galati, , Romania

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Oradea, , Romania

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Ploieşti, , Romania

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Ploieşti, , Romania

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Târgu Mureş, , Romania

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Timișoara, , Romania

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Barnaul, , Russia

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Kemerovo, , Russia

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Moscow, , Russia

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Novosibirsk, , Russia

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S. Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Banská Bystrica, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Bratislava, , Slovakia

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Dolný Kubín, , Slovakia

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Komárno, , Slovakia

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Levice, , Slovakia

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Levice, , Slovakia

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Lučenec, , Slovakia

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Prievidza, , Slovakia

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Trenčín, , Slovakia

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Cape Town, , South Africa

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Cape Town, , South Africa

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Durban, , South Africa

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Johannesburg, , South Africa

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Johannesburg, , South Africa

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Observatory, Cape Town, , South Africa

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Port Elizabeth, , South Africa

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Pretoria, , South Africa

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Pretoria, , South Africa

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Richards Bay, , South Africa

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Soweto, , South Africa

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Soweto, , South Africa

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Lugo, Lugo, Spain

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Madrid, Madrid, Spain

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Taichung, , Taiwan

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Taipei, , Taiwan

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Taipei, , Taiwan

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Taipei, , Taiwan

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Taipei, , Taiwan

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Taoyuan, , Taiwan

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Bangkok, , Thailand

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Bangkok, , Thailand

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Chiang Mai, , Thailand

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Kharkiv, , Ukraine

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Kiev, , Ukraine

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Kiev, , Ukraine

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Lviv, , Ukraine

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Mykolaiv, , Ukraine

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Poltava, , Ukraine

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Ternopil, , Ukraine

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Vinnitsa, , Ukraine

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Zaporizhzhya, , Ukraine

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Zaporizhzhya, , Ukraine

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Bexhill-on-Sea, , United Kingdom

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Birmingham, , United Kingdom

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Cardiff, , United Kingdom

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Chorley, , United Kingdom

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Dundee, , United Kingdom

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Glasgow, , United Kingdom

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Liverpool, , United Kingdom

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Liverpool, , United Kingdom

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London, , United Kingdom

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Manchester, , United Kingdom

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Reading, , United Kingdom

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Salford, , United Kingdom

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Countries

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Italy United States Australia Brazil Bulgaria Canada Czechia Denmark Estonia Germany Hungary India Israel Lithuania Malaysia Mexico Poland Romania Russia Slovakia South Africa Spain Taiwan Thailand Ukraine United Kingdom

Other Identifiers

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2009-014986-22

Identifier Type: -

Identifier Source: secondary_id

NC25113

Identifier Type: -

Identifier Source: org_study_id