Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer

NCT ID: NCT01015625

Last Updated: 2024-08-19

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-24

Study Completion Date

2022-07-31

Brief Summary

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Primary Operation in synchronous metastasized invasive breast cancer to evaluate the use of local therapy

Detailed Description

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This study is a prospective, randomized, multicentre, study concerning the influence of local treatment on the patients with synchronous metastasized breast cancer. Patients will be stratified at inclusion according to the centre, the menopausal status (pre-menopausal, post-menopausal), the hormone-receptor status (ER-/PR-/not determinable; any PR and/or Er+), the HER-2 status (positive vs. negative/not determinable), the grading (G1/G2/not determinable vs. G3), location of metastases (visceral ± vs bone only), organs with metastases (single organ vs multiple organs) and use of first line chemotherapy (anthracycline ± vs. taxane vs others). Thereafter patients will be randomly assigned to receive either local therapy of the breast (lumpectomy or mastectomy + axillary surgery /± radiotherapy) versus no local therapy. Systemic therapy will be administered at the centers policy.

Conditions

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Synchronous Metastasized Breast Cancer Circulating Tumor Cells

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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A: Surgical Therapy

Local therapy consists of lumpectomy or mastectomy with or without radiotherapy (according to center tumor board decision) with a resection free margin of at least 1 mm or more demonstrated on paraffin embedded histological sections. Intraoperative frozen sections are allowed but not definitive for margin assessment. Sentinel node biopsy may be performed and has always to be followed by axillary dissection of level I and II (axillary surgery level I and II is mandatory).

Group Type OTHER

Surgery

Intervention Type PROCEDURE

lumpectomy or mastectomy with or without radiotherapy. Sentinel biopsy followed by axillary dissection (level I-II)

B: Surgery on Demand

In Arm B (no local therapy) it may be necessary to perform local therapy on demand (surgery, radiotherapy). Reasons may be uncontrolled bleeding or infected exulcerations with a septic component and no treatment benefit from conservative therapy. This will be considered as protocol deviation. However, the patient's follow up is recorded and data are available for analyses as intention to treat.

Group Type OTHER

Surgery on Demand

Intervention Type PROCEDURE

if necessary local therapy on demand

Interventions

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Surgery

lumpectomy or mastectomy with or without radiotherapy. Sentinel biopsy followed by axillary dissection (level I-II)

Intervention Type PROCEDURE

Surgery on Demand

if necessary local therapy on demand

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients age ≥ 18 years
* Eastern Cooperative Oncology Group Performance Status is 0 -2
* Untreated synchronous metastasized invasive carcinoma of the breast with the primary tumor in situ (bilateral synchronous metastasized breast cancer patients are eligible)
* The primary tumor must be identified and may be any size, however, primary resection with resection free margins must be possible
* Invasive adenocarcinoma of the breast on histological examination
* The metastatic site must be identified by radiological assessment(Computer Tomography of the chest and the abdomen OR ultrasound and chest x ray for visceral metastases; bone scan AND/OR computer tomography AND/OR magnetic resonance for bone metastases). A biopsy is not necessary.
* Written informed consent must be obtained and documented prior to beginning any protocol specific procedures and according to local regulatory requirements
* able to comply with the protocol requirements during the treatment and follow-up period.

Exclusion Criteria

* Patients in whom a R0 resection (microscopic free margins) is clinically questionable
* Inflammatory cancer
* Patients with a brain metastasis
* Patients who are not eligible for general anesthesia and operations
* Patients without metastatic breast cancer (patients with a tumor marker value (CEA, CA15-3) above normal levels without the radiological proven evidence of metastases are not eligible for the study)
* Patients with a second untreated malignancy
* Any previous malignancy treated with curative intent and the patient has not been disease-free for 5 years - exceptions are: (a)carcinoma in situ of the cervix, (b)squamous carcinoma of the skin, (c)basal cell carcinoma of the skin
* Patients with any recurrent cancer disease
* Pregnant or lactating women
* Patients are not allowed to be part of another local therapy trial
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role collaborator

Amgen

INDUSTRY

Sponsor Role collaborator

Hoffmann-La Roche

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role collaborator

Sanofi

INDUSTRY

Sponsor Role collaborator

Wyeth-Lederle Pharma GmbH

INDUSTRY

Sponsor Role collaborator

GlaxoSmithKline

INDUSTRY

Sponsor Role collaborator

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role collaborator

Fond of the Viennese Mayor

OTHER

Sponsor Role collaborator

Austrian Breast & Colorectal Cancer Study Group

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Florian Fitzal, MD

Role: STUDY_DIRECTOR

Austrian Breast & Colorectal Cancer Study Group

Michael Gnant, MD

Role: STUDY_DIRECTOR

Austrian Breast & Colorectal Cancer Study Group

Guenther Steger, MD

Role: STUDY_DIRECTOR

Austrian Breast & Colorectal Cancer Study Group

Locations

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Hospital Guessing

Güssing, Burgenland, Austria

Site Status

Hospital Oberpullendorf

Oberpullendorf, Burgenland, Austria

Site Status

Ordination Dr. Wette

Saint Veit A. D. Glan, Carinthia, Austria

Site Status

Gynaegological Medical University Graz

Graz, Styria, Austria

Site Status

Medical University Graz, Oncology

Graz, Styria, Austria

Site Status

Medical University of Innsbruck

Innsbruck, Tyrol, Austria

Site Status

Ordensklinikum Linz GmbH - BHS Linz, Coop. Study Group

Linz, Upper Austria, Austria

Site Status

Ordensklinikum Linz GmbH - Elisabethinen Linz

Linz, Upper Austria, Austria

Site Status

General Hospital Linz

Linz, Upper Austria, Austria

Site Status

Klinikum Wels-Grieskirchen GmbH

Wels, Upper Austria, Austria

Site Status

State Hospital Feldkirch

Feldkirch, Vorarlberg, Austria

Site Status

Paracelsus Medical University Salzburg-Oncology, Coop. Group

Salzburg, , Austria

Site Status

Medical University of Vienna-General Hospital Vienna

Vienna, , Austria

Site Status

Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

References

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Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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ABCSG 28

Identifier Type: OTHER

Identifier Source: secondary_id

ABCSG 28 / POSYTIVE

Identifier Type: -

Identifier Source: org_study_id

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