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Adipogenic Capacity as a Mediator of Weight Gain

NCT ID: NCT01015508

Last Updated: 2012-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2012-11-30

Brief Summary

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To demonstrate differences in response of subjects with a high, low or medium predisposition for weight regain after weight reduction in terms of: body composition; energy expenditure; physical activity; and adipogenic capacity.

Detailed Description

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The risk for weight regain after weight loss is a major problem for the current obesity treatments, and is largely genetically determined. It is believed that an elucidation of the genetic component in the prognosis of weight management could assist in the development of more effective and individually tailored treatments. However, current research on the genetic component of weight management, and in particular weight regain, is still limited and data available are sometimes inconsistent. The current research proposal aims to identify groups with a high, low or medium predisposition for weight regain, based on a genetic profile and to demonstrate differences in the response of these subjects to a weight maintenance period after weight reduction in terms of body composition, physical activity, adipogenic capacity and energy expenditure.

Conditions

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Obesity

Keywords

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Weight loss and maintenance body composition energy expenditure adipogenic capacity physical activity

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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High predisposition

High predisposition for weight regain

Group Type OTHER

Very Low Energy Diet (VLED)

Intervention Type OTHER

a VLED (Modifast) for 2 months in order to reduce body weight

Weight maintenance

Intervention Type OTHER

10 months

low predisposition

low predisposition for weight regain

Group Type OTHER

Very Low Energy Diet (VLED)

Intervention Type OTHER

a VLED (Modifast) for 2 months in order to reduce body weight

Weight maintenance

Intervention Type OTHER

10 months

Medium predisposition

Medium predisposition for weight regain

Group Type OTHER

Very Low Energy Diet (VLED)

Intervention Type OTHER

a VLED (Modifast) for 2 months in order to reduce body weight

Weight maintenance

Intervention Type OTHER

10 months

Interventions

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Very Low Energy Diet (VLED)

a VLED (Modifast) for 2 months in order to reduce body weight

Intervention Type OTHER

Weight maintenance

10 months

Intervention Type OTHER

Other Intervention Names

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Modifast

Eligibility Criteria

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Inclusion Criteria

* BMI 28-35
* healthy, no medication
* no smoking
* stable weight (no weight loss/gain \> 5kg in 3 months prior to study)

Exclusion Criteria

* 28\< BMI \>35
* use of medication
* smoking
* weight loss/gain \> 5kg in 3 months prior to study
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Klaas R Westerterp, Prof

Role: PRINCIPAL_INVESTIGATOR

Maastricht University

Locations

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Dept. of Human Biology (Maastricht University)

Maastricht, Limburg, Netherlands

Site Status

Countries

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Netherlands

References

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Camps SG, Verhoef SP, Roumans N, Bouwman FG, Mariman EC, Westerterp KR. Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure. Nutr Metab (Lond). 2015 Oct 24;12:37. doi: 10.1186/s12986-015-0034-1. eCollection 2015.

Reference Type DERIVED
PMID: 26500687 (View on PubMed)

Camps SG, Verhoef SP, Westerterp KR. Weight loss-induced reduction in physical activity recovers during weight maintenance. Am J Clin Nutr. 2013 Oct;98(4):917-23. doi: 10.3945/ajcn.113.062935. Epub 2013 Aug 28.

Reference Type DERIVED
PMID: 23985804 (View on PubMed)

Verhoef SP, Camps SG, Gonnissen HK, Westerterp KR, Westerterp-Plantenga MS. Concomitant changes in sleep duration and body weight and body composition during weight loss and 3-mo weight maintenance. Am J Clin Nutr. 2013 Jul;98(1):25-31. doi: 10.3945/ajcn.112.054650. Epub 2013 May 22.

Reference Type DERIVED
PMID: 23697706 (View on PubMed)

Camps SG, Verhoef SP, Westerterp KR. Weight loss, weight maintenance, and adaptive thermogenesis. Am J Clin Nutr. 2013 May;97(5):990-4. doi: 10.3945/ajcn.112.050310. Epub 2013 Mar 27.

Reference Type DERIVED
PMID: 23535105 (View on PubMed)

Verhoef SP, Camps SG, Bouwman FG, Mariman EC, Westerterp KR. Physiological response of adipocytes to weight loss and maintenance. PLoS One. 2013;8(3):e58011. doi: 10.1371/journal.pone.0058011. Epub 2013 Mar 7.

Reference Type DERIVED
PMID: 23505452 (View on PubMed)

Other Identifiers

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HumBio_Westerterp09

Identifier Type: -

Identifier Source: org_study_id