Measured Hypocretin Levels and Recovery After Hip Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-07-31

Study Completion Date

2018-12-31

Brief Summary

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A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.

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Detailed Description

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Conditions

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Osteoarthritis, Hip

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Male or female
* Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic.

Exclusion Criteria

* Diagnosed psychiatric disease (except mild depression)
* Any diagnoses CNS disease or dementia
* History of stroke
* History of untreated thyroid disease
* Difficulty in airway management (ventilation and/or intubation)
* Body Mass Index (BMI) \> 35 kg/m2

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No