Role of Exercise for Wound Healing in the Larynx

NCT ID: NCT01009632

Last Updated: 2009-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-02-29

Study Completion Date

2005-03-31

Brief Summary

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The purpose of this study is to explore quantitatively the hypothesis that "resonant voice," may enhance recovery from acute laryngeal phonotrauma, based on molecular assays from human laryngeal secretions and secondarily, clinical tests.

Detailed Description

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The objective is to use the following operationalized question: Does a voicing mode shown to correspond to high-amplitude, low impact vocal cord oscillations, "resonant voice," improve the amount and time-course of recovery from acute phonotrauma, compared to vocal rest or spontaneous speech, as measured with molecular assays (primarily) and with behavioral and clinical tests (secondarily)?

Conditions

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Acute Phonotrauma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Voice rest

Group Type EXPERIMENTAL

Voice rest

Intervention Type BEHAVIORAL

4-hr of complete refrain from any voice use

Resonant voice exercise

Group Type EXPERIMENTAL

Resonant voice

Intervention Type BEHAVIORAL

4-hr of resonant voice exercise

Spontaneous speech

Group Type EXPERIMENTAL

Spontaneous speech

Intervention Type BEHAVIORAL

Interventions

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Resonant voice

4-hr of resonant voice exercise

Intervention Type BEHAVIORAL

Voice rest

4-hr of complete refrain from any voice use

Intervention Type BEHAVIORAL

Spontaneous speech

Intervention Type BEHAVIORAL

Other Intervention Names

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4-hr of conversational (normal) voice use

Eligibility Criteria

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Inclusion Criteria

* males and females who have had voice training and feel they are able to produce loud voice safely;
* ages 18-49;
* generally healthy;
* normal hearing bilaterally at 20 dB to 8,000 Hz; and
* demonstrated ability to produce "resonant voice" during training as determined by the examiner perceptually.

Exclusion Criteria

* current chronic voice problems;
* current medications that are determined to possibly influence voice (e.g. diuretics, decongestants);
* heightened gag reflex;
* small nasal passage;
* deviated septum; and
* known or suspected allergy to anesthetics.
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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University of Pittsburgh

Principal Investigators

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Katherine Verdolini Abbott, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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Univesity of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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DC005643

Identifier Type: -

Identifier Source: org_study_id

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