Autologous Cell Therapy for Female Stress Urinary Incontinence

NCT ID: NCT01008943

Last Updated: 2021-07-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-02

Study Completion Date

2012-09-21

Brief Summary

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The Autologous Cell Therapy for Female SUI study is a clinical trial to determine the safety and potential effectiveness of a single dose of 200 million Cook MyoSite Autologous Muscle Derived Cells for treatment of Stress Urinary Incontinence.

Detailed Description

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Conditions

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Stress Urinary Incontinence

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Autologous Muscle Derived Cells

Intervention Type BIOLOGICAL

Urethral injection of autologous muscle-derived cells

Interventions

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Autologous Muscle Derived Cells

Urethral injection of autologous muscle-derived cells

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* SUI with normal detrusor activity confirmed with urodynamics
* Bladder capacity \>200 ml
* Incontinence has not shown any improvement for at least -6 months
* Failed prior treatments (e.g., behavior modification, bladder exercises, biofeedback, electrical stimulation, bulking injections, urethral suspensions and/or drug therapy)

Exclusion Criteria

* Known vesicoureteral reflux, vaginal prolapse beyond the introitus, or other significant pelvic floor abnormalities with high pressure instability
* Neuromuscular disorder (e.g., muscular dystrophy, multiple sclerosis)
* Uncontrolled diabetes
* Pregnant, lactating, or plans to become pregnant during course of the study
* Morbid obesity (defined as 100 pounds over their ideal body weight, or BMI ≥40) and not expected to benefit from treatment
* Current or acute conditions involving cystitis or urethritis
* Scheduled to receive radiation treatment to the vicinity, or history of radiation treatment to the urethra or adjacent structures
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Cook MyoSite

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lesley K. Carr, MD

Role: PRINCIPAL_INVESTIGATOR

Sunnybrook Health Sciences Center

Locations

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Foothills Medical Centre

Calgary, Alberta, Canada

Site Status

Sunnybrook Health Sciences Center

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Related Links

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http://www.ncbi.nlm.nih.gov/pubmed/24582537

Autologous muscle derived cells for treatment of stress urinary incontinence in women

Other Identifiers

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09-013

Identifier Type: -

Identifier Source: org_study_id

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