A Study to Assess Food Effect on the Pharmacokinetics of Fimasartan in Healthy Male Volunteers

NCT ID: NCT01007409

Last Updated: 2009-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Brief Summary

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To assess food effect on the pharmacokinetics of fimasartan in healthy male volunteers.

Detailed Description

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Conditions

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Healthy

Keywords

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To assess food effect on the pharmacokinetics of fimasartan in healthy male volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

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Group B

Period 1: fed control → Period 2: fasted control

Group Type ACTIVE_COMPARATOR

Fimasartan

Intervention Type DRUG

Period 1: administration of fimasartan 240mg at 9:00am, 30 minutes after the breakfast Period 2: administration of fimasartan 240mg at 9:00am, without the breakfast

Group A

Period 1: fasted control → Period 2: fed control

Group Type ACTIVE_COMPARATOR

Fimasartan

Intervention Type DRUG

Period 1: administration of fimasartan 240mg at 9:00am, without the breakfast Period 2: administration of fimasartan 240mg at 9:00am, 30 minutes after the breakfast

Interventions

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Fimasartan

Period 1: administration of fimasartan 240mg at 9:00am, 30 minutes after the breakfast Period 2: administration of fimasartan 240mg at 9:00am, without the breakfast

Intervention Type DRUG

Fimasartan

Period 1: administration of fimasartan 240mg at 9:00am, without the breakfast Period 2: administration of fimasartan 240mg at 9:00am, 30 minutes after the breakfast

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age: 20 - 45 years
* sex: male
* body weight: greater than 55 kg
* written informed consent

Exclusion Criteria

* known allergy to Fimasartan
* existing cardiac or hematological diseases
* existing hepatic and renal diseases
* existing gastrointestinal diseases
* acute or chronic diseases which could affect drug absorption or metabolism history of any serious psychological disorder
* abnormal diet which could affect drug absorption or metabolism
* positive drug or alcohol screening
* smokers of 10 or more cigarettes per day
* participation in a clinical trial during the last 60 days prior to the start of the study
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Boryung Pharmaceutical Co., Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Boryung

Other Identifiers

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A657-BR-CT-111

Identifier Type: -

Identifier Source: org_study_id