A Study of OPC-262 in Patients With Type 2 Diabetes

NCT ID: NCT00997282

Last Updated: 2014-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

255 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2010-10-31

Brief Summary

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The purpose of this clinical study is to evaluate the superiority of the efficacy of OPC-262 (2.5 mg, and 5 mg) to placebo in patients with type 2 diabetes after 24 week treatment in a double-blind fashion and to evaluate the safety of OPC-262 to placebo.

Detailed Description

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Conditions

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Diabetes Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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OPC-262 2.5 mg

orally administered once daily for 24 weeks

Group Type EXPERIMENTAL

OPC-262 2.5 mg

Intervention Type DRUG

orally administered once daily for 24 weeks

OPC-262 5 mg

orally administered once daily for 24 weeks

Group Type EXPERIMENTAL

OPC-262 5 mg

Intervention Type DRUG

orally administered once daily for 24 weeks

Placebo

orally administered once daily for 24 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

orally administered once daily for 24 weeks

Interventions

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OPC-262 2.5 mg

orally administered once daily for 24 weeks

Intervention Type DRUG

OPC-262 5 mg

orally administered once daily for 24 weeks

Intervention Type DRUG

Placebo

orally administered once daily for 24 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Type 2 diabetes patients with HbA1C above 6.5% and below 10%
2. Patients who are capable of giving informed consent
3. Patients who are able to take contraceptive measures to avoid pregnancy of the patient or the patient's partner for the entire study period and for 4 weeks after the study (end of the post-observation period)

Exclusion Criteria

1. Patients with type 1 diabetes mellitus, patients with diabetes mellitus due to other specified drugs, mechanisms or diseases, and patients with gestational diabetes mellitus
2. Patients with a medical history of diabetic coma
3. Patients with poorly-controlled hypertension
4. Patients with heart failure
5. Patients with a complication of active hepatitis or hepatic cirrhosis
6. Patients undergoing treatment of glomerular diseases other than diabetic nephropathy
7. Patients with a history or complication of malignant tumor
Minimum Eligible Age

20 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kyowa Kirin Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Department of Clinical Research and Development, Otsuka Pharmaceutical Co., Ltd.

Principal Investigators

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Kaatsuhisa Saito

Role: STUDY_CHAIR

OPCJ

Locations

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Chubu Region, , Japan

Site Status

Chugoku Region, , Japan

Site Status

Kansai Region, , Japan

Site Status

Kanto Region, , Japan

Site Status

Kyushu Region, , Japan

Site Status

Shikoku Region, , Japan

Site Status

Tohoku Region, , Japan

Site Status

Countries

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Japan

Other Identifiers

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JapicCTI-090904

Identifier Type: -

Identifier Source: secondary_id

262-09-001

Identifier Type: -

Identifier Source: org_study_id

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