Efficacy Study of Metadoxine SR Formulation in Attention Deficit Hyperactivity Disorder (ADHD) Subjects

NCT ID: NCT00995085

Last Updated: 2017-03-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2010-10-31

Brief Summary

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This clinical study is designed to evaluate the safety and tolerability of a single oral administration of a Metadoxine slow release formulation to subjects diagnosed as having ADHD. Study also assess cognitive effects of such drug administration.

Detailed Description

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Primary outcome measure is the safety and tolerability of study drug after a single dosing.

Additional outcomes include commission error rate from the TOVA test. The result is measured as standard score in % compared to the values of the normal population.

Exploratory outcome measures include:

1. TOVA measures like response time , variability, omissions etc.
2. Subtests from Wechsler: digit memory, digit-number signs etc

Conditions

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Attention Deficit Hyperactivity Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Metadoxine SR

Metadoxine is a pyrolate salt of Pyridoxine

Group Type EXPERIMENTAL

Extended Release Metadoxine

Intervention Type DRUG

one oral 1400mg dose (2 tablets)

Interventions

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Extended Release Metadoxine

one oral 1400mg dose (2 tablets)

Intervention Type DRUG

Other Intervention Names

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Metadoxine, Metadoxil

Eligibility Criteria

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Inclusion Criteria

* age 18-45
* diagnosed as ADHD

Exclusion Criteria

* PDD patients
* head injured patients
* patients suffering from heart, lung, liver, kidney, intestinal, endocrine an neurological diseases and patients who are sensitive to vitamin B
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcobra Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Iris Manor, MD

Role: PRINCIPAL_INVESTIGATOR

Geha MC, Israel

Locations

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ADHD Unit, Geha MHC, Israel

Petah Tikva, , Israel

Site Status

Countries

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Israel

Other Identifiers

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0012-09-GEH

Identifier Type: -

Identifier Source: org_study_id

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