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Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias

NCT ID: NCT00991484

Last Updated: 2010-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2011-06-30

Brief Summary

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Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's (matrix metallo proteinases) and TIMP's (tissue inhibitor of metallo proteinases) will be measured.

Detailed Description

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Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.

Other examinations performed on the patients enrolled in this study:

* Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
* Beightons score to evaluate the degree of joint hypermobility.

Conditions

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Hernia

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Study Groups

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control group

No interventions assigned to this group

individuals from hernia-family

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* adults over 18 years
* adults must be members of a family where there are presence of hernias in minimum generation.

Exclusion Criteria

* infections
* pregnant
* mentally ill patients
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Herlev Hospital

OTHER

Sponsor Role lead

Responsible Party

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Herlev Hospital, Department of surgical Gastroenterology

Principal Investigators

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Jacob Rosenberg, Prof. MD

Role: STUDY_DIRECTOR

Herlev Hospital

Jakob Burcharth, MD

Role: PRINCIPAL_INVESTIGATOR

Herlev Hospital

Locations

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Herlev Hospital

Dk-2730, Herlev, Herlev, Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Jakob Burcharth, MD

Role: CONTACT

[email protected]
0045 44884488 ext. 89434

Facility Contacts

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jakob Burcharth, MS

Role: primary

[email protected]
004544884488

Other Identifiers

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H-4-2009-123

Identifier Type: -

Identifier Source: org_study_id