To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden

NCT ID: NCT00991419

Last Updated: 2013-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2011-08-31

Brief Summary

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The purpose of this study is to compare PET measurements of fibrillar amyloid burden using \[18F\]AZD4694.

Detailed Description

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Conditions

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Alzheimer's Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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A

\[18F\]4694

Group Type EXPERIMENTAL

[18F]AZD4694

Intervention Type DRUG

\[18F\]AZD4694 PET Ligand administered at Visit 1, 30 days following screening and at visit 4 for some of the participants.

Interventions

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[18F]AZD4694

\[18F\]AZD4694 PET Ligand administered at Visit 1, 30 days following screening and at visit 4 for some of the participants.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female, of any race or/ethnicity
* ECG, vital signs, and clinical laboratory values are within normal limits at enrollment or deemed not clinically significant by the physician

Exclusion Criteria

* Significant recent (within 6 months) history of neurological (including stroke) or psychiatric disorder or substance abuse
* Participated in a PET study within the last 12 months
* Pregnancy or lactation
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric M Reiman, MD

Role: PRINCIPAL_INVESTIGATOR

Banner Alzheimer's Institute

Locations

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Research Site

Phoenix, Arizona, United States

Site Status

Countries

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United States

Other Identifiers

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D2750N00006

Identifier Type: -

Identifier Source: org_study_id

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