Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections

NCT ID: NCT00990392

Last Updated: 2015-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-30

Study Completion Date

2011-01-31

Brief Summary

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The purpose of the study is to determine if the overall central venous catheter related infection rate can be reduced by the application of Polysporin Triple Therapy ointment to the insertion site.

Detailed Description

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Previous studies in the dialysis population have found a reduction in local and system central venous catheter related infections with the application of topical antibiotics to the insertion point. One such study found a mortality benefit with Polysporin Triple Therapy ointment. We intend to determine if this preparation can reduce overall line infection rates in the ICU environment through its application at the time of line insertion and twice more the following week.

Conditions

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Blood Stream Infections Skin Diseases, Infectious

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Polysporin Triple Therapy

Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.

Group Type EXPERIMENTAL

Polysporin Triple Therapy ointment

Intervention Type DRUG

Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.

Placebo

Petroleum jelly

Group Type PLACEBO_COMPARATOR

Petroleum Jelly

Intervention Type OTHER

Petroleum jelly applied to the insertion point at the time of CVC placement and twice within the first week.

Interventions

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Polysporin Triple Therapy ointment

Polysporin Triple Therapy ointment applied to the insertion point at the time of CVC placement and twice within the first week.

Intervention Type DRUG

Petroleum Jelly

Petroleum jelly applied to the insertion point at the time of CVC placement and twice within the first week.

Intervention Type OTHER

Other Intervention Names

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Polysporin Triple Therapy (gramicidin, polymixin, bacitracin) Vaseline

Eligibility Criteria

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Inclusion Criteria

* all patients admitted to the ICU requiring a central venous catheter

Exclusion Criteria

* previous line infection during same ICU stay
* CVC for hemodialysis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fraser Health

OTHER

Sponsor Role lead

Responsible Party

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Steve Reynolds

Critical care Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Steven Reynolds, MD

Role: PRINCIPAL_INVESTIGATOR

Fraser Health Authority

Locations

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Royal Columbian Hospital

New Westminster, British Columbia, Canada

Site Status

Countries

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Canada

References

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Lok CE, Stanley KE, Hux JE, Richardson R, Tobe SW, Conly J. Hemodialysis infection prevention with polysporin ointment. J Am Soc Nephrol. 2003 Jan;14(1):169-79. doi: 10.1097/01.asn.0000038688.76195.a4.

Reference Type BACKGROUND
PMID: 12506149 (View on PubMed)

James MT, Conley J, Tonelli M, Manns BJ, MacRae J, Hemmelgarn BR; Alberta Kidney Disease Network. Meta-analysis: antibiotics for prophylaxis against hemodialysis catheter-related infections. Ann Intern Med. 2008 Apr 15;148(8):596-605. doi: 10.7326/0003-4819-148-8-200804150-00004.

Reference Type BACKGROUND
PMID: 18413621 (View on PubMed)

Other Identifiers

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Kerrie-333333

Identifier Type: -

Identifier Source: org_study_id

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