Individual Differences in Diabetes Risk: Role of Sleep Disturbances
NCT ID: NCT00989976
Last Updated: 2014-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
16 participants
INTERVENTIONAL
2009-02-28
2014-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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8.5 h sleep
Subjects will have normal sleep times
normal sleep times
8.5 h bedtimes
restricted bedtimes
4.5 h bedtimes
bedtime restriction
4.5 h restricted bedtimes
Interventions
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normal sleep times
8.5 h bedtimes
bedtime restriction
4.5 h restricted bedtimes
Eligibility Criteria
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Inclusion Criteria
* normal weight or modestly overweight (BMI ≤ 27 kg/m2 for women, BMI ≤ 28 kg/m2 for men),
* normal findings on clinical examination, normal routine laboratory tests results, normal EKG, no history of psychiatric, endocrine, cardiac or sleep disorders.
* Only subjects who have regular life styles (no shift work, no travel across time zone during the past 4 weeks), habitual bedtimes between 7.0-8.5 hours, and do not take medications will be recruited.
* An overnight polysomnography will be performed to rule out sleep-disordered breathing (apnea-hypopnea index \> 5/hour) and periodic limb movement disorder (PLM arousal index \>1/hour).
* Women taking hormonal contraceptive therapy and pregnant women will be excluded. In women, all studies will be initiated in the early follicular phase.
Exclusion Criteria
* Habitual alcohol use of more than 2 1 drink per day.
* Excessive caffeine intake of more than 300 mg per day and individuals with a metal implant or another metal object in their body.
We estimate that we will need to recruit at least 60-70 individuals to obtain two gender-matched groups of 16 individuals with either low or high SWA.
18 Years
29 Years
ALL
Yes
Sponsors
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University of Chicago
OTHER
Responsible Party
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Principal Investigators
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Eve Van Cauter, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Locations
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The University of Chicago
Chicago, Illinois, United States
Countries
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Other Identifiers
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DOD PR064727
Identifier Type: -
Identifier Source: secondary_id
#16028A
Identifier Type: -
Identifier Source: org_study_id