Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
PHASE2
1 participants
INTERVENTIONAL
2009-10-31
2010-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Manual Therapy
Subjects will receive oscillatory (grade 1 \& 2) manual knee mobilization for 15 minutes at various knee range of motion positions.
Manual Therapy
Grade 1 and 2 oscillatory manual mobilization of the tibiofemoral joint at various ranges of motion.
Therapeutic Exercise
Subjects will perform 15 minutes of combined resistance exercise and aerobic exercise.
Therapeutic Exercise
Subjects will perform 5 minutes of lower extremity cycle ergometer with minimal resistance followed by 10 minutes of resistance exercise to the quadriceps at 3 tibiofemoral positions (0 degrees, 30 degrees and 60 degrees of knee flexion).
Control
Subjects will watch a 15 minute instructional video on a health topic.
Video Observation
Subjects will watch a 15 minute video on a health topic unrelated to knee osteoarthritis.
Interventions
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Manual Therapy
Grade 1 and 2 oscillatory manual mobilization of the tibiofemoral joint at various ranges of motion.
Therapeutic Exercise
Subjects will perform 5 minutes of lower extremity cycle ergometer with minimal resistance followed by 10 minutes of resistance exercise to the quadriceps at 3 tibiofemoral positions (0 degrees, 30 degrees and 60 degrees of knee flexion).
Video Observation
Subjects will watch a 15 minute video on a health topic unrelated to knee osteoarthritis.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Intra-articular knee injection within one month of study inception,
* A history of exercise induced or uncontrolled angina within three months of the study entry,
* Severe dyspnea at rest,
* Previous bilateral total knee arthroplasty,
* Pregnancy, OR
* The absence of knee pain at the time of recruitment for the study.
18 Years
89 Years
ALL
Yes
Sponsors
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Texas Tech University Health Sciences Center
OTHER
Responsible Party
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Texas Tech University Health Sciences Center
Principal Investigators
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Dan Poulsen, PhD
Role: PRINCIPAL_INVESTIGATOR
Texas Tech University Health Sciences Center
Locations
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Texas Tech University Health Sciences Center
Lubbock, Texas, United States
Countries
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References
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Wright A. Hypoalgesia post-manipulative therapy: a review of a potential neurophysiological mechanism. Man Ther. 1995 Nov;1(1):11-6. doi: 10.1054/math.1995.0244.
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Knott EM, Tune JD, Stoll ST, Downey HF. Increased lymphatic flow in the thoracic duct during manipulative intervention. J Am Osteopath Assoc. 2005 Oct;105(10):447-56.
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de Miguel Mendieta E, Cobo Ibanez T, Uson Jaeger J, Bonilla Hernan G, Martin Mola E. Clinical and ultrasonographic findings related to knee pain in osteoarthritis. Osteoarthritis Cartilage. 2006 Jun;14(6):540-4. doi: 10.1016/j.joca.2005.12.012.
Conaghan P, D'Agostino MA, Ravaud P, Baron G, Le Bars M, Grassi W, Martin-Mola E, Wakefield R, Brasseur JL, So A, Backhaus M, Malaise M, Burmester G, Schmidely N, Emery P, Dougados M. EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility. Ann Rheum Dis. 2005 Dec;64(12):1710-4. doi: 10.1136/ard.2005.038026. Epub 2005 May 5.
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986 Aug;29(8):1039-49. doi: 10.1002/art.1780290816.
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Other Identifiers
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L10-004
Identifier Type: -
Identifier Source: org_study_id