Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)

NCT ID: NCT00988299

Last Updated: 2011-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-12-31

Brief Summary

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In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
2. increase in resting metabolic rate 48 hours after exercise;
3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

Detailed Description

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Conditions

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Aging

Keywords

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older NEAT exercise RMR energy expenditure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Interventions

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exercise

exercise sessions at 45% and 60% of maximum effort

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Women
2. Age 60-75 years
3. normal weight
4. Weight-stable (± 5%) within the previous 3 months
5. Non-smoking for last year
6. Able to provide own transportation to study visits
7. Not currently involved in any other research study
8. Willing and able to participate in all aspects of the trial including research testing
9. Willing to give informed consent to participate

Exclusion Criteria

1. Self-reported significant cardiovascular disease
2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
3. Medications known to affect exercise performance or metabolism
4. Excess caffeine use (\> 500mg/day)
5. Any self-reported contraindications to exercise
6. Clinical depression
7. Abnormal cognitive function -
Minimum Eligible Age

60 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xuewen Wang, PhD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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K99AG031297

Identifier Type: NIH

Identifier Source: secondary_id

View Link

09-0864

Identifier Type: -

Identifier Source: org_study_id