A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course

NCT ID: NCT00988052

Last Updated: 2021-12-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

839 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-10

Study Completion Date

2017-07-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to make laquinimod 0.6 mg available for all subjects who completed the placebo-controlled MS-LAQ-301 study according to the protocol and to evaluate the long-term safety, tolerability and effect on disease course of daily oral laquinimod 0.6 mg in subjects with relapsing multiple sclerosis.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Relapsing Multiple Sclerosis

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Relapsing Multiple Sclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Laquinimod

One capsule containing 0.6 mg laquinimod to be administered orally once daily.

Group Type EXPERIMENTAL

Laquinimod

Intervention Type DRUG

One capsule containing 0.6 mg laquinimod to be administered orally once daily.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Laquinimod

One capsule containing 0.6 mg laquinimod to be administered orally once daily.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Subjects must have completed the Termination visit of MS-LAQ-301 (completion of all Termination visit activities) according to the MS-LAQ-301 protocol.
2. Women of child-bearing potential must practice an acceptable method of birth control \[acceptable methods of birth control in this open label extension phase include: surgical sterilization, intrauterine devices, oral contraceptive, contraceptive patch (or hormone-releasing vaginal ring), long-acting injectable contraceptive, partner's vasectomy or double-barrier method (condom or diaphragm with spermicide)\] during the study and up to 30 days after the last dose of the study drug..
3. Subjects must be willing and able to comply with the protocol requirements for the duration of the study.
4. Subjects must be able to comprehend, sign and date a written informed consent prior to entering the MS-LAQ-301E study.

Exclusion Criteria

1. Premature discontinuation from the MS-LAQ-301 study, for any reason.
2. Pregnancy \[according to urine dipstick β-HCG test performed at Baseline (Month 0E) visit\] or breastfeeding.
3. Subjects with clinically significant or unstable medical or surgical condition detected or worsened during the MS-LAQ-301 study, which preclude safe participation and completion of the MS-LAQ-301E study. Acute exacerbation of MS will not exclude participation in the MS-LAQ-301E study.
4. Use of inhibitors of CYP3A4 within 2 weeks prior to baseline visit (V0E, Month 0E).
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Giancarlo Comi, Prof., MD

Role: PRINCIPAL_INVESTIGATOR

U.O.Neurology-Neurorehabilitation and Clinical Neurophysiology

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Teva Investigational Site 1076

Phoenix, Arizona, United States

Site Status

Teva Investigational Site 1090

Centennial, Colorado, United States

Site Status

Teva Investigational Site 1088

Fort Collins, Colorado, United States

Site Status

Teva Investigational Site 1102

Northbrook, Illinois, United States

Site Status

Teva Investigational Site 1081

Fort Wayne, Indiana, United States

Site Status

Teva Investigational Site 1083

Des Moines, Iowa, United States

Site Status

Teva Investigational Site 1086

Kansas City, Kansas, United States

Site Status

Teva Investigational Site 1101

Lexington, Kentucky, United States

Site Status

Teva Investigational Site 1096

Farmington Hills, Michigan, United States

Site Status

Teva Investigational Site 1093

Minneapolis, Minnesota, United States

Site Status

Teva Investigational Site 1098

St Louis, Missouri, United States

Site Status

Teva Investigational Site 1082

New York, New York, United States

Site Status

Teva Investigational Site 1073

Winston-Salem, North Carolina, United States

Site Status

Teva Investigational Site 1097

Fargo, North Dakota, United States

Site Status

Teva Investigational Site 1084

Dayton, Ohio, United States

Site Status

Teva Investigational Site 1092

Oklahoma City, Oklahoma, United States

Site Status

Teva Investigational Site 1100

Hershey, Pennsylvania, United States

Site Status

Teva Investigational Site 1075

Lubbock, Texas, United States

Site Status

Teva Investigational Site 1078

San Antonio, Texas, United States

Site Status

Teva Investigational Site 1085

Milwaukee, Wisconsin, United States

Site Status

Teva Investigational Site 3300

Klagenfurt, , Austria

Site Status

Teva Investigational Site 3303

Linz, , Austria

Site Status

Teva Investigational Site 3302

Sankt Pölten, , Austria

Site Status

Teva Investigational Site 5901

Pleven, , Bulgaria

Site Status

Teva Investigational Site 5904

Sofia, , Bulgaria

Site Status

Teva Investigational Site 5903

Sofia, , Bulgaria

Site Status

Teva Investigational Site 5900

Sofia, , Bulgaria

Site Status

Teva Investigational Site 5905

Sofia, , Bulgaria

Site Status

Teva Investigational Site 5902

Varna, , Bulgaria

Site Status

Teva Investigational Site 1132

Bedford, Nova Scotia, Canada

Site Status

Teva Investigational Site 1126

London, Ontario, Canada

Site Status

Teva Investigational Site 1128

Ottawa, Ontario, Canada

Site Status

Teva Investigational Site 1134

Toronto, Ontario, Canada

Site Status

Teva Investigational Site 1130

Greenfield Park, Quebec, Canada

Site Status

Teva Investigational Site 1129

Montreal, Quebec, Canada

Site Status

Teva Investigational Site 1131

Sherbrooke, Quebec, Canada

Site Status

Teva Investigational Site 5417

Olomouc, , Czechia

Site Status

Teva Investigational Site 5416

Ostrava - Poruba, , Czechia

Site Status

Teva Investigational Site 5504

Tallinn, , Estonia

Site Status

Teva Investigational Site 5505

Tartu, , Estonia

Site Status

Teva Investigational Site 3525

Besançon, , France

Site Status

Teva Investigational Site 3527

Bron, , France

Site Status

Teva Investigational Site 3526

Clermont-Ferrand, , France

Site Status

Teva Investigational Site 3524

Lille, , France

Site Status

Teva Investigational Site 3528

Marseille, , France

Site Status

Teva Investigational Site 3529

Rennes, , France

Site Status

Teva Investigational Site 8100

Tbilisi, , Georgia

Site Status

Teva Investigational Site 8101

Tbilisi, , Georgia

Site Status

Teva Investigational Site 3247

Bayreuth, , Germany

Site Status

Teva Investigational Site 3241

Berlin, , Germany

Site Status

Teva Investigational Site 3238

Berlin, , Germany

Site Status

Teva Investigational Site 3248

Bochum, , Germany

Site Status

Teva Investigational Site 3245

Dresden, , Germany

Site Status

Teva Investigational Site 3237

Emden, , Germany

Site Status

Teva Investigational Site 3242

Erbach im Odenwald, , Germany

Site Status

Teva Investigational Site 3240

Erfurt, , Germany

Site Status

Teva Investigational Site 3249

Freiburg im Breisgau, , Germany

Site Status

Teva Investigational Site 3236

Hamburg, , Germany

Site Status

Teva Investigational Site 3246

Hamburg, , Germany

Site Status

Teva Investigational Site 3239

Hanover, , Germany

Site Status

Teva Investigational Site 3243

Heidelberg, , Germany

Site Status

Teva Investigational Site 3251

Münster, , Germany

Site Status

Teva Investigational Site 3250

Trier, , Germany

Site Status

Teva Investigational Site 3244

Ulm, , Germany

Site Status

Teva Investigational Site 5115

Budapest, , Hungary

Site Status

Teva Investigational Site 5114

Debrecen, , Hungary

Site Status

Teva Investigational Site 5116

Miskolc, , Hungary

Site Status

Teva Investigational Site 5117

Veszprém, , Hungary

Site Status

Teva Investigational Site 8031

Haifa, , Israel

Site Status

Teva Investigational Site 8030

Jerusalem, , Israel

Site Status

Teva Investigational Site 8033

Ramat Gan, , Israel

Site Status

Teva Investigational Site 8032

Tel Aviv, , Israel

Site Status

Teva Investigational Site 3044

Catania, , Italy

Site Status

Teva Investigational Site 3045

Fidenza, , Italy

Site Status

Teva Investigational Site 3042

Gallarate, , Italy

Site Status

Teva Investigational Site 3046

Grosseto, , Italy

Site Status

Teva Investigational Site 3038

Milan, , Italy

Site Status

Teva Investigational Site 555

Milan, , Italy

Site Status

Teva Investigational Site 3039

Milan, , Italy

Site Status

Teva Investigational Site 3041

Palermo, , Italy

Site Status

Teva Investigational Site 3040

Rome, , Italy

Site Status

Teva Investigational Site 5704

Kaunas, , Lithuania

Site Status

Teva Investigational Site 5705

Šiauliai, , Lithuania

Site Status

Teva Investigational Site 3810

Nieuwegein, , Netherlands

Site Status

Teva Investigational Site 3809

Nijmegen, , Netherlands

Site Status

Teva Investigational Site 5322

Częstochowa, , Poland

Site Status

Teva Investigational Site 5319

Gmina Końskie, , Poland

Site Status

Teva Investigational Site 5320

Gorzów Wielkopolski, , Poland

Site Status

Teva Investigational Site 5316

Katowice, , Poland

Site Status

Teva Investigational Site 5318

Kielce, , Poland

Site Status

Teva Investigational Site 5317

Krakow, , Poland

Site Status

Teva Investigational Site 5315

Lodz, , Poland

Site Status

Teva Investigational Site 5325

Warsaw, , Poland

Site Status

Teva Investigational Site 5208

Bucharest, , Romania

Site Status

Teva Investigational Site 5210

Cluj-Napoca, , Romania

Site Status

Teva Investigational Site 5212

Constanța, , Romania

Site Status

Teva Investigational Site 5211

Târgu Mureş, , Romania

Site Status

Teva Investigational Site 5209

Timișoara, , Romania

Site Status

Teva Investigational Site 5021

Moscow, , Russia

Site Status

Teva Investigational Site 5028

Nizhny Novgorod, , Russia

Site Status

Teva Investigational Site 5027

Novosibirsk, , Russia

Site Status

Teva Investigational Site 5030

Perm, , Russia

Site Status

Teva Investigational Site 5026

Saint Petersburg, , Russia

Site Status

Teva Investigational Site 5025

Saint Petersburg, , Russia

Site Status

Teva Investigational Site 5024

Saint Petersburg, , Russia

Site Status

Teva Investigational Site 5022

Saint Petersburg, , Russia

Site Status

Teva Investigational Site 5023

Saint Petersburg, , Russia

Site Status

Teva Investigational Site 5029

Yekaterinburg, , Russia

Site Status

Teva Investigational Site 6100

Belgrade, , Serbia

Site Status

Teva Investigational Site 6102

Niš, , Serbia

Site Status

Teva Investigational Site 3132

Barcelona, , Spain

Site Status

Teva Investigational Site 3134

Barcelona, , Spain

Site Status

Teva Investigational Site 3144

Barcelona, , Spain

Site Status

Teva Investigational Site 3140

Beade-Pontevedra, , Spain

Site Status

Teva Investigational Site 3142

Getafe, , Spain

Site Status

Teva Investigational Site 3135

Lleida, , Spain

Site Status

Teva Investigational Site 3133

Madrid, , Spain

Site Status

Teva Investigational Site 3146

Madrid, , Spain

Site Status

Teva Investigational Site 3137

Murcia, , Spain

Site Status

Teva Investigational Site 3138

Pontevedra, , Spain

Site Status

Teva Investigational Site 3136

Salt, , Spain

Site Status

Teva Investigational Site 3139

Santiago de Compostela, , Spain

Site Status

Teva Investigational Site 3143

Valencia, , Spain

Site Status

Teva Investigational Site 4204

Stockholm, , Sweden

Site Status

Teva Investigational Site 4205

Stockholm, , Sweden

Site Status

Teva Investigational Site 4206

Stockholm, , Sweden

Site Status

Teva Investigational Site 8201

Izmir, , Turkey (Türkiye)

Site Status

Teva Investigational Site 5803

Dnipropetrovsk, , Ukraine

Site Status

Teva Investigational Site 5802

Kyiv, , Ukraine

Site Status

Teva Investigational Site 5804

Kyiv, , Ukraine

Site Status

Teva Investigational Site 5800

Lviv, , Ukraine

Site Status

Teva Investigational Site 5801

Vinnytsia, , Ukraine

Site Status

Teva Investigational Site 3425

Liverpool, , United Kingdom

Site Status

Teva Investigational Site 3424

London, , United Kingdom

Site Status

Teva Investigational Site 3422

Sheffield, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Latvia United States Austria Bulgaria Canada Czechia Estonia France Georgia Germany Hungary Israel Italy Lithuania Netherlands Poland Romania Russia Serbia Spain Sweden Turkey (Türkiye) Ukraine United Kingdom

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2009-012989-30

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

MS-LAQ-301E

Identifier Type: -

Identifier Source: org_study_id