Comparison Azathioprine to Mesalazine for the Prevention of Postoperative Recurrence in the Crohn Disease

NCT ID: NCT00976690

Last Updated: 2011-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-10-31

Study Completion Date

2010-12-31

Brief Summary

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To show the superiority of Azathioprine comparing Mesalazine in the prevention of postoperative recurrence in Crohn's Disease.

Detailed Description

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Conditions

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Crohn Disease

Keywords

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Crohn's Disease Ileocolic resection Endoscopic recurrence Ileocolic or colon resection (>50cm)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Azathioprine : 2mg/kg/day

Group Type ACTIVE_COMPARATOR

Azathioprine OR Mesalazine

Intervention Type DRUG

Azathioprine : 2mg/kg/day Mesalazine : 4g/day

2

Mesalazine : 4g/day

Group Type ACTIVE_COMPARATOR

Azathioprine OR Mesalazine

Intervention Type DRUG

Azathioprine : 2mg/kg/day Mesalazine : 4g/day

Interventions

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Azathioprine OR Mesalazine

Azathioprine : 2mg/kg/day Mesalazine : 4g/day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* more than 18 years old
* Clinical remission at inclusion time (CDAI\<150)
* Having ileocolonic or colon resection 21 days before inclusion
* Resection \> 50cm or subtotal colectomy with ileorectal anastomosis

Exclusion Criteria

* Intolerance to one of both study treatment
* Liver failure (TP\<60%)
* Renal Failure (Creatinine \< Lab results)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marc LEMANN, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Locations

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Chu Amiens

Amiens, , France

Site Status

Chu Besancon

Besançon, , France

Site Status

CHU CAEN

Caen, , France

Site Status

Hopital Beaujon

Clichy, , France

Site Status

Chru Lille

Lille, , France

Site Status

Hopital Lariboisiere

Paris, , France

Site Status

Hopital Saint Louis

Paris, , France

Site Status

Hopital St Antoine

Paris, , France

Site Status

Hopital Cochin

Paris, , France

Site Status

Hopital Haut Leveque

Pessac, , France

Site Status

Chu Reims

Reims, , France

Site Status

Chu Rennes

Rennes, , France

Site Status

Chu Toulouse

Toulouse, , France

Site Status

Chu Tours

Tours, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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GETAID 2001-1

Identifier Type: -

Identifier Source: org_study_id