The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia

NCT ID: NCT00971698

Last Updated: 2011-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2010-08-31

Brief Summary

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The spleen in Sickle Cell Anemia and Sickle Cell Thalassemia is usually enlarged in the first years of life but the immune protection provided is considered insufficient. In homozygous Sickle cell patients the spleen usually developed recurrent infarcts and after the first decade of age become fibrotic. Acute splenic sequestration is also frequent in those patients and this is considered as an indication for splenectomy.

In comparison in Sickle cell thalassemia patients, hypersplenism is more frequent.

The purpose of this study is to compare the clinical and laboratory issues related to the spleen in two groups of Sickle cell patients.

Detailed Description

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Clinical and laboratory characteristics related to the spleen in SCA patients will be studied.

Two groups of patient will be compared, a group of Sickle cell patients (Homozygous) and a second group of patients with Sickle cell beta thalassemia.

In those patients that splenectomy was performed the incidence of infections will be recorded besides the indications for splenectomy and the incidence of thrombotic events or thrombocytosis.

Conditions

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Sickle Cell Anemia Thalassemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Sickle Cell Patients

Patients with homozygous Sickle Cell Anemia

No interventions assigned to this group

Sickle Cell Thalassemia

Patients with Sickle Cell Thalassemia

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All the patients followed up at the Pediatric Hematology Unit

Exclusion Criteria

* Patients lost from follow up of with insufficient data
Minimum Eligible Age

1 Year

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HaEmek Medical Center, Israel

OTHER

Sponsor Role lead

Responsible Party

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Dr Koren Ariel

Head of Pediatric Hematology Unit and Pediatric Dpt B

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center

Afula, , Israel

Site Status

Countries

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Israel

Other Identifiers

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0135-08-EMC

Identifier Type: -

Identifier Source: org_study_id

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