A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe

NCT ID: NCT00969969

Last Updated: 2016-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

236 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2016-07-31

Brief Summary

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This study will evaluate whether Cartiva is an effective treatment for individuals with osteoarthritis of the great toe.

Detailed Description

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Conditions

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Osteoarthritis of First Metatarsalphalangeal Joint

Keywords

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First MTP Joint Hallux Rigidus Hallux Limitus Cartilage Replacement Osteoarthritis First MTP Joint Osteoarthritis Big Toe Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arthrodesis

Fusion

Group Type ACTIVE_COMPARATOR

Arthrodesis

Intervention Type DEVICE

arthrodesis using screws and/or a plate

Cartiva

Synthetic Cartilage Implant

Group Type EXPERIMENTAL

Cartiva

Intervention Type DEVICE

Cartiva Synthetic Cartilage Implant

Interventions

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Arthrodesis

arthrodesis using screws and/or a plate

Intervention Type DEVICE

Cartiva

Cartiva Synthetic Cartilage Implant

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* ≥ 18 years of age
* Osteoarthritis of the first metatarsophalangeal joint and is a candidate for arthrodesis
* Presence of good bone stock
* Capable of completing self-administered questionnaires

Exclusion Criteria

* \< 18 years of age
* Osteoarthritis of the first metatarsophalangeal joint, though is not a candidate for arthrodesis
* Active bacterial infection of the foot
* Additional ipsilateral limb (hip, knee, ankle, or foot) pathology that requires active treatment (surgery or brace)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cartiva, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Judith Baumhauer

Role: PRINCIPAL_INVESTIGATOR

University of Rochester

Locations

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University of Calgary

Calgary, Alberta, Canada

Site Status

University of Alberta

Edmonton, Alberta, Canada

Site Status

St. Paul's Hospital

Vancouver, British Columbia, Canada

Site Status

Horizon Health Network

Fredericton, New Brunswick, Canada

Site Status

Queen Elizabeth Science Centre

Halifax, Nova Scotia, Canada

Site Status

St. Michael's Hospital

Toronto, Ontario, Canada

Site Status

Frimley Park Hospital - Surrey Foot and Ankle Clinic

Frimley, Camberley, United Kingdom

Site Status

St. George's Hospital

Tooting, London, United Kingdom

Site Status

Royal National Orthopaedic Hospital - Stanmore Foot & Ankle Clinic

Stanmore, Middlesex, United Kingdom

Site Status

Northern General Hospital NHS Trusts - Sheffield Orthopaedics

Sheffield, South Yorkshire, United Kingdom

Site Status

Royal Surrey County Hospital

Guildford, Surrey, United Kingdom

Site Status

Torbay Hospital

South Devon, Torquay, United Kingdom

Site Status

Countries

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Canada United Kingdom

Other Identifiers

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PTC-0031

Identifier Type: -

Identifier Source: org_study_id