Population Pharmacokinetic-pharmacodynamic (PK-PD) Modeling of Co-administered Gabapentin in Neuropathic Pain

NCT ID: NCT00967707

Last Updated: 2011-10-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-08-31
• Study Completion Date: 2011-09-30

Brief Summary

The primary objective of this study is to develop a pharmacokinetic (PK) and a pharmacokinetic-pharmacodynamic (PK-PD) model for gabapentin in patients with neuropathic pain.

The secondary objectives are to investigate whether adjuvant therapy of venlafaxine or donepezil contributes to 1) improved analgesic efficacy and 2) improved health-related quality of life (assessed by the SF-36 questionnaire) in neuropathic pain patients treated with gabapentin.

Detailed Description

Neuropathic pain is estimated to affect 2-3 % of the population and the condition is difficult to treat with conventional analgesics. The drug of first choice is typically a tricyclic antidepressant drug (TCA) or the antiepileptic drug gabapentin. TCAs have well-documented effects, but the use is commonly interrupted due to intolerable adverse effects. Gabapentin, on the other hand, is generally well tolerated in patients. Clinical trials have proven that gabapentin is efficacious for neuropathic pain of various origins. Nevertheless, monotherapy is seldom sufficient for the management of severe neuropathic pain. Combination therapy, e.g. of gabapentin and an analgesic with complementary mechanism of action, may be a rational strategy to obtain improved results at lower doses and with fewer side effects. Although many neuropathic pain patients receive a combination of drugs, there is an absence of clinical evidence for optimal drug combinations.

Gabapentin binds to the alpha-2-delta subunit on presynaptic voltage-gated calcium channels, which results in modulation of the release of neurotransmitters from presynaptic nerve terminals. Recent studies in animal models of neuropathic pain have shown that gabapentin is effective on supraspinal structures, to activate the descending pain inhibitory noradrenergic-cholinergic cascade. Thus, it might be possible to potentiate the analgesic effect of gabapentin by concomitant administration of a drug able to prolong the action of noradrenaline or acetylcholine in the synapse cleft. In this study, the adjuvant effect of the noradrenaline and serotonin reuptake inhibitor venlafaxine and the cholinesterase inhibitor donepezil will be investigated in neuropathic pain patients treated with gabapentin.

The study consists of two periods. All patients are treated with gabapentin in the first period, and receive randomised adjuvant therapy of venlafaxine or donepezil in the second period. Repeated pain intensity ratings and blood samples for analysis of gabapentin plasma concentrations will be collected over one dosing interval of gabapentin at the end of each period.

Data will be analysed by means of nonlinear mixed effect modeling. The NONMEM programme will be used to develop models describing the PK and the PK-PD relationship of gabapentin in patients with neuropathic pain. The potential effect of concomitant treatment with venlafaxine or donepezil will be evaluated by covariate analysis in the developed PK and PK-PD models of gabapentin.

Conditions

Post-traumatic Neuropathic Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Gabapentin + venlafaxine

Group Type: ACTIVE_COMPARATOR

gabapentin and venlafaxine

Intervention Type: DRUG

Week 1-6: Gabapentin monotherapy (titration to individual maximum tolerated dose or maximum 800 mg 3 times daily).

Week 7-12: Venlafaxine 75 mg once daily is added.

Gabapentin + donepezil

Group Type: ACTIVE_COMPARATOR

gabapentin and donepezil

Intervention Type: DRUG

Week 1-6: Gabapentin monotherapy (titration to individual maximum tolerated dose or maximum 800 mg 3 times daily).

Week 7-12: Donepezil 5 mg once daily is added.

Interventions

gabapentin and venlafaxine

Week 1-6: Gabapentin monotherapy (titration to individual maximum tolerated dose or maximum 800 mg 3 times daily).

Week 7-12: Venlafaxine 75 mg once daily is added.

Intervention Type: DRUG

gabapentin and donepezil

Week 1-6: Gabapentin monotherapy (titration to individual maximum tolerated dose or maximum 800 mg 3 times daily).

Week 7-12: Donepezil 5 mg once daily is added.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Diagnosis of post-traumatic neuropathic pain
• Spontaneous pain intensity ≥ 40 on VAS or ≥ 4 on NRS
• Man or woman ≥ 18 years old
• Informed consent to study participation

Exclusion Criteria

• Presence of other type of pain as strong as or stronger than the neuropathic pain
• Impaired kidney function (GFR < 30 ml/min)
• Uncontrolled cardiovascular disease/hypertonia
• Uncontrolled narrow-angle glaucoma
• Uncontrolled pulmonary disease
• Epilepsia
• Pregnancy
• Nursing
• Woman of childbearing potential not using contraception or planning to become pregnant during the study period
• Disability to understand and cooperate with study procedures
• Allergy to study medications
• Concomitant participation in other clinical study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Copenhagen

OTHER

Sponsor Role: collaborator

Uppsala University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stephen H. Butler, MD

Role: PRINCIPAL_INVESTIGATOR

Uppsala University

Locations

Multidisciplinary Pain Centre, Uppsala University Hospital

Uppsala, , Sweden

Countries

Sweden

Other Identifiers

EudraCT number 2009-010783-41

Identifier Type: -

Identifier Source: secondary_id

GBPPKPD-09

Identifier Type: -

Identifier Source: org_study_id