Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
NCT ID: NCT00965354
Last Updated: 2024-09-19
Study Results
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View full resultsBasic Information
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COMPLETED
131 participants
OBSERVATIONAL
2009-12-31
2011-02-28
Brief Summary
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Detailed Description
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The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Influenza diagnosis
Patients admitted to hospital with a suspected or confirmed influenza diagnosis on admission
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Wellcome Trust
OTHER
Medical Research Council
OTHER_GOV
Imperial College London
OTHER
Responsible Party
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Principal Investigators
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Peter JM Openshaw
Role: PRINCIPAL_INVESTIGATOR
Imperial College London
Locations
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Alder Hey Children's Foundation NHS Trust
Liverpool, , United Kingdom
Royal Liverpool University Hospital
Liverpool, , United Kingdom
Liverpool Women's NHS Foundation Trust
Liverpool, , United Kingdom
Aintree Hospitals NHS Trust
Liverpool, , United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust
London, , United Kingdom
Royal Brompton and Harefield NHS Foundation Trust
London, , United Kingdom
Imperial College Healthcare NHS Trust
London, , United Kingdom
Wirral University Teaching Hospital NHS Foundation Trust
Metropolitan Borough of Wirral, , United Kingdom
Countries
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References
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Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18.
Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators; Moffatt MF, O'Garra A, Openshaw PJM. Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0328-y.
Other Identifiers
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09/H0709/52
Identifier Type: OTHER
Identifier Source: secondary_id
09/MRE00/67
Identifier Type: OTHER
Identifier Source: secondary_id
CRO1367
Identifier Type: -
Identifier Source: org_study_id
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