An 18 Week Efficacy and Safety Study of Saxagliptin and Metformin XR Combination in Subjects With Type 2 Diabetes

NCT ID: NCT00960076

Last Updated: 2011-09-27

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

282 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2010-10-31

Brief Summary

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The purpose of this study is to compare reduction in A1C for subjects taking Saxagliptin and Metformin XR vs. uptitrated Metformin XR.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Saxagliptin

Group Type EXPERIMENTAL

Saxagliptin

Intervention Type DRUG

5mg oral tablet once daily

Metformin XR

Intervention Type DRUG

750mg, 2 tablets once daily

2

Metformin Extended Release

Group Type ACTIVE_COMPARATOR

Metformin XR

Intervention Type DRUG

500mg oral tablet once daily

Metformin XR

Intervention Type DRUG

750mg, 2 tablets once daily

Interventions

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Saxagliptin

5mg oral tablet once daily

Intervention Type DRUG

Metformin XR

500mg oral tablet once daily

Intervention Type DRUG

Metformin XR

750mg, 2 tablets once daily

Intervention Type DRUG

Other Intervention Names

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Onglyza

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetics taking metformin IR or XR greater than or equal to 850mg and less than or equal to 1500mg only for at least 8 weeks prior to screening
* A1c: 7.5-11% (at screening)
* BMI less than or equal to 45 kg/m2

Exclusion Criteria

* Significant cardiovascular history
* Active liver disease, renal impairment
Minimum Eligible Age

18 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boaz Hirschberg, MD

Role: STUDY_DIRECTOR

AstraZeneca

Vivian Fonseca, MD

Role: PRINCIPAL_INVESTIGATOR

Tulane University

Locations

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Research Site

Jonesboro, Arkansas, United States

Site Status

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Anaheim, California, United States

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Fountain Valley, California, United States

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Los Angeles, California, United States

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Pasadena, California, United States

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Sacramento, California, United States

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Gainesville, Florida, United States

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Wellington, Florida, United States

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Chicago, Illinois, United States

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Springfield, Illinois, United States

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Indianapolis, Indiana, United States

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St Louis, Missouri, United States

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Salisbury, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Columbus, Ohio, United States

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Marion, Ohio, United States

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Simpsonville, South Carolina, United States

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Bristol, Tennessee, United States

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Alexandria, Virginia, United States

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Burke, Virginia, United States

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Manassas, Virginia, United States

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Barranquilla, Atlántico, Colombia

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Barranquilla, , Colombia

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Bogotá, , Colombia

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Curridabat, Provincia de San José, Costa Rica

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Los Yoses, Provincia de San José, Costa Rica

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Heredia, , Costa Rica

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México, D.f., Mexico

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Durango, Durango, Mexico

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Guadalajara, Jalisco, Mexico

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Zapopan, Jalisco, Mexico

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Cuernavaca, Morelos, Mexico

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Querétaro City, Querétaro, Mexico

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Lima, , Peru

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Countries

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United States Colombia Costa Rica Mexico Peru

References

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Fonseca V, Zhu T, Karyekar C, Hirshberg B. Adding saxagliptin to extended-release metformin vs. uptitrating metformin dosage. Diabetes Obes Metab. 2012 Apr;14(4):365-71. doi: 10.1111/j.1463-1326.2011.01553.x. Epub 2012 Jan 18.

Reference Type DERIVED
PMID: 22192246 (View on PubMed)

Other Identifiers

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D1680L00005

Identifier Type: -

Identifier Source: org_study_id