Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis

NCT ID: NCT00959036

Last Updated: 2013-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

252 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-01-31

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of ATN-103 when administered to subjects with active rheumatoid arthritis compared with placebo. All subjects must be on a stable dose and route of methotrexate.

Detailed Description

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Conditions

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Active Rheumatoid Arthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Treatment Group 1

ATN-103 10 mg every 4 weeks until week 12

Group Type EXPERIMENTAL

ATN-103

Intervention Type DRUG

10 mg every 4 weeks until week 12

Methotrexate

Intervention Type DRUG

Treatment Group 2

ATN-103 10 mg every 8 weeks until week 12

Group Type EXPERIMENTAL

ATN-103

Intervention Type DRUG

10 mg every 8 weeks until week 12

Methotrexate

Intervention Type DRUG

Treatment Group 3

ATN-103 30 mg every 4 weeks until week 12

Group Type EXPERIMENTAL

ATN-103

Intervention Type DRUG

30 mg every 4 weeks until week 12

Methotrexate

Intervention Type DRUG

Treatment Group 4

ATN-103 80 mg every 4 weeks until week 12

Group Type EXPERIMENTAL

ATN-103

Intervention Type DRUG

80 mg every 4 weeks until week 12

Methotrexate

Intervention Type DRUG

Treatment Group 5

ATN-103 80 mg every 8 weeks until week 12

Group Type EXPERIMENTAL

ATN-103

Intervention Type DRUG

80 mg every 8 weeks until week 12

Methotrexate

Intervention Type DRUG

Treatment Group 6

Placebo every 4 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo every 4 weeks

Methotrexate

Intervention Type DRUG

Interventions

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ATN-103

10 mg every 4 weeks until week 12

Intervention Type DRUG

ATN-103

10 mg every 8 weeks until week 12

Intervention Type DRUG

ATN-103

30 mg every 4 weeks until week 12

Intervention Type DRUG

ATN-103

80 mg every 4 weeks until week 12

Intervention Type DRUG

ATN-103

80 mg every 8 weeks until week 12

Intervention Type DRUG

Placebo

Placebo every 4 weeks

Intervention Type DRUG

Methotrexate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of active rheumatoid arthritis on a stable background of methotrexate (7.5-25 mg weekly).

Exclusion Criteria

* Any significant health problem other than rheumatoid arthritis
* Any clinically significant laboratory abnormalities
* Any prior use of B cell-depleting therapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ablynx, a Sanofi company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Josefin-Beate Holz, MD

Role: STUDY_DIRECTOR

Ablynx, a Sanofi company

Locations

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Investigational Site

Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Peoria, Arizona, United States

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Scottsdale, Arizona, United States

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Riverside, California, United States

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Upland, California, United States

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Bridgeport, Connecticut, United States

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Newark, Delaware, United States

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Lake Mary, Florida, United States

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Ocala, Florida, United States

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Orlando, Florida, United States

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Port Orange, Florida, United States

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Vero Beach, Florida, United States

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Coeur d'Alene, Idaho, United States

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Frederick, Maryland, United States

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West Yarmouth, Massachusetts, United States

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Lansing, Michigan, United States

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Freehold, New Jersey, United States

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Albuquerque, New Mexico, United States

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Mineola, New York, United States

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Charlotte, North Carolina, United States

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Hickory, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Columbus, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Lake Oswego, Oregon, United States

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Allentown, Pennsylvania, United States

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Columbia, South Carolina, United States

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Myrtle Beach, South Carolina, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Tacoma, Washington, United States

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Brussels, Belgium, Belgium

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Leuven, , Belgium

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Winnipeg, Manitoba, Canada

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Kitchener, Ontario, Canada

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Ottawa, Ontario, Canada

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St. Catharines, Ontario, Canada

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Toronto, Ontario, Canada

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Québec, Quebec, Canada

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Vogelsang, Gommern, Germany

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Budapest, , Hungary

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Debrecen, , Hungary

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Kemerovo, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Novosibirsk, , Russia

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Novosibirsk, , Russia

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Orenburg, , Russia

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Petrozavodsk, , Russia

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Ryazan, , Russia

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Vladimir, , Russia

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Yaroslavl, , Russia

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Yaroslavl, , Russia

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Belgrade, Serbia, Serbia

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Niška Banja, , Serbia

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Berea, KwaZulu-Natal, South Africa

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Cape Town, , South Africa

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Cape Town, , South Africa

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Pretoria, , South Africa

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Zurich, Canton of Zurich, Switzerland

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Chur, , Switzerland

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Countries

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United States Belgium Canada Germany Hungary Russia Serbia South Africa Switzerland

Other Identifiers

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B2271003

Identifier Type: -

Identifier Source: secondary_id

3242K1-2000

Identifier Type: -

Identifier Source: org_study_id

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