Bispectral Index Monitoring of Sedation During Endoscopic Retrograde Cholangiopancreaticography

NCT ID: NCT00952458

Last Updated: 2012-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

144 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2010-05-31

Brief Summary

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This randomized study investigates the benefits of an additional Bispectral Index monitoring of depth of sedation during endoscopic retrograde cholangiopancreaticography. A bispectral index (BIS) monitor is a neurophysiological monitoring device which continually analyses a patient's electroencephalograms during general anaesthesia to assess the level of consciousness during anaesthesia.

Detailed Description

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Conditions

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Gastrointestinal Endoscopy Sedation

Keywords

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Safety Midazolam and propofol sedation ERCP Bispectral Index monitoring

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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BIS monitoring

Dosing of sedatives with BIS monitoring

Group Type EXPERIMENTAL

BIS monitoring

Intervention Type DEVICE

Neuromonitoring of depth of sedation with Bispectral Index

Standard monitoring

Dosing of sedatives without BIS monitoring

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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BIS monitoring

Neuromonitoring of depth of sedation with Bispectral Index

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Indication for ERCP (Endoscopic Retrograde Cholangiopancreatography) with midazolam and propofol sedation

Exclusion Criteria

* Missing informed consent
* ASA V
* Preexisting neurological deficit
* Known pregnancy
* Hypotension (RRsys\<90mmHg), bradycardia (HR\<50/min), hypoxia (SaO2\<90%)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic - MITG

INDUSTRY

Sponsor Role collaborator

Technical University of Munich

OTHER

Sponsor Role lead

Responsible Party

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Klinikum rechts der Isar der Technischen Universität München

Principal Investigators

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Stefan von Delius, MD

Role: PRINCIPAL_INVESTIGATOR

Klinikum rechts der Isar der Technischen Universität München

Locations

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Klinikum rechts der Isar der Technischen Universität München

Munich, Bavaria, Germany

Site Status

Countries

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Germany

References

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von Delius S, Thies P, Rieder T, Wagenpfeil S, Herberich E, Karagianni A, Frimberger E, Meining A, Ludwig L, Ebert MP, Schulte-Frohlinde E, Neu B, Prinz C, Schmid RM, Huber W. Auditory evoked potentials compared with bispectral index for monitoring of midazolam and propofol sedation during colonoscopy. Am J Gastroenterol. 2009 Feb;104(2):318-25. doi: 10.1038/ajg.2008.73. Epub 2009 Jan 20.

Reference Type BACKGROUND
PMID: 19190608 (View on PubMed)

Other Identifiers

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2094/08

Identifier Type: -

Identifier Source: org_study_id