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Carotid Intima-media Thickness (IMT) and Large-vessel Atherosclerosis by Multidetector Computed Tomography (MDCT)

NCT ID: NCT00949169

Last Updated: 2009-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

71 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-04-30

Study Completion Date

2007-07-31

Brief Summary

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The aim of this study was to investigate whether carotid IMT can predict the presence of more advanced atherosclerosis such as carotid stenosis, coronary or intracranial artery disease by MDCT and whether MDCT could be useful next step for more aggressive treatment modality in Korean type 2 diabetic patients.

Detailed Description

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We evaluated mean/maximal carotid IMT in seventy-one type 2 diabetic subjects, and defined increased carotid IMT as maximal IMT ≥ 1.0 mm. Multidetector CT (MDCT) and pulse wave velocity (PWV) were taken to evaluate carotid artery stenosis (CS), coronary artery disease (CAD), intracranial arterial lesion (ICA), and peripheral artery disease (PAD). We compared prevalence of large artery stenosis according to carotid IMT group and evaluated whether maximal IMT ≥ 1.0 mm could predict for significant CAD by MDCT. We performed invasive coronary angiography in some patients (N=14) and analyzed association for degrees of CAD between two angiographic methods.

Conditions

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Type 2 Diabetes

Keywords

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Atherosclerosis Carotid IMT Multidetector CT Type 2 diabetes

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Carrotid IMT group according to maximal IMT

We defined increased IMT group as whom had maximal IMT ≥ 1.0 mm.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetic patients who had multiple cardiovascular risk factors were recruited.
* Patients who had atypical chest pain, EKG abnormality (ischemic ST-T changes or abnormal Q-wave), or history of previous cardiovascular disease were also included.

Exclusion Criteria

* Acute coronary SD, serum Cr\>1.4 mg/dL, history of allergy to iodinated contrast dye were excluded.
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eulji University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Kyung Wan Min, MD., PhD.

Role: PRINCIPAL_INVESTIGATOR

Department of Internal Medicine, Eulji University Hospital

Locations

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Eulji University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Eulji07-34

Identifier Type: -

Identifier Source: org_study_id