Rationale for New Topical Anthroponotic Cutaneous Leishmaniasis (ACL) Treatment in Kabul
NCT ID: NCT00947362
Last Updated: 2025-08-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
134 participants
INTERVENTIONAL
2004-08-01
2007-12-15
Brief Summary
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* to evaluate the clinical efficacy of electro-thermo-cauterisation (ETC) followed by moist wound treatment versus ETC followed by moist wound treatment plus 0.05 % pharmaceutical chlorite that has been used in three European countries (Germany, Austria and Switzerland) in wound care management for more than 20 years;
* to judge whether early wound care management would present a viable improvement to the actual anti-parasitic treatments mostly neglecting the chronic wound problem and to evaluate its long-term effect on immunity through relapse control 6 months after wound healing.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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ETC + DAC N-055
Electro-thermo-coagulation
DAC N-055
moist wound treatment plus 0.05 % pharmaceutical chlorite
ETC + physiological saline
Electro-thermo-coagulation
saline
physiological saline
Interventions
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Electro-thermo-coagulation
DAC N-055
moist wound treatment plus 0.05 % pharmaceutical chlorite
saline
physiological saline
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
5 Years
99 Years
ALL
No
Sponsors
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German Medical Service (GMS) in Kabul
OTHER
University of Freiburg
OTHER
Waisenmedizin e. V. Promoting Access to Essential Medicine
OTHER
Responsible Party
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Kurt-Wilhelm Stahl
Chairman
Locations
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German Medical Service
Kabul, Kabul, Afghanistan
Countries
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References
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Jebran AF, Schleicher U, Steiner R, Wentker P, Mahfuz F, Stahl HC, Amin FM, Bogdan C, Stahl KW. Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul. PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2694. doi: 10.1371/journal.pntd.0002694. eCollection 2014 Feb.
Other Identifiers
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No grant or contract number
Identifier Type: -
Identifier Source: secondary_id
169/04
Identifier Type: -
Identifier Source: org_study_id
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