Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2011-04-30

Brief Summary

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Brain imaging tests are routinely used to detect the presence of a brain tumor or to evaluate the response to treatment. Sometimes the images obtained are not specific and the only way to establish a diagnosis is by obtaining a tissue sample. The hypotheses of the study is to determine if multimodal MR technique will provide tissue signatures that differentiate between tumor progression and treatment related necrosis in high grade glioma patients.

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Detailed Description

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Conditions

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Recurrent High Grade Gliomas

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Research MRI

High Grade Glioma patients who show progression based on MRI

3T MRI

Intervention Type DEVICE

The introduction of the 3T scanners provides a potential opportunity to improve the quality of imaging in neuro-oncology.

Interventions

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3T MRI

The introduction of the 3T scanners provides a potential opportunity to improve the quality of imaging in neuro-oncology.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Histologically proven high grae glioma with central pathology review at DHMC
* Age 18 equal to or greater than 18 years
* Karnofsky performance greater or equal to 60%
* Patients must have received radiation therapy and chemotherapy but should not have received any anti-angiogenesis therapy.