Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2009-10-31
2010-10-31
Brief Summary
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Plant sterols can play an important role in lowering plasma cholesterol. The extent to which plant sterols can reduce plasma cholesterol levels depends on the intake scenario. We suggest that the difference in these effects depends on gastric emptying and bile secretion.
Objective of the study:
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant sterol containing drink prior to, during and after a standardized meal.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
TRIPLE
Study Groups
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Dietary Supplement: Plant sterol containing drink
The test products used in the study will be a commercially available PS drink and a ready to eat macaroni meal
Plant sterol containing drink
The test products used in the study will be a commercially available PS drink and a ready to eat macaroni meal
Standard macaroni meal
The test products used in the study will be a commercially available PS drink and a ready to eat macaroni meal
Interventions
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Plant sterol containing drink
The test products used in the study will be a commercially available PS drink and a ready to eat macaroni meal
Standard macaroni meal
The test products used in the study will be a commercially available PS drink and a ready to eat macaroni meal
Eligibility Criteria
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Inclusion Criteria
* Sex: male
* Age: 18-55 years
* Body Mass Index (BMI): 20-25 kg/m2
Exclusion Criteria
* Use of any medication on regular basis.
* Use of paracetamol prior to treatment (≤ 48 hour).
* Use of plant sterol/stanol enriched products or supplements 3 months prior to the study.
* Blood donations less than three months previous to study enrolment.
* Known hypersensitivity or allergy towards paracetamol.
* Hyperlipidaemia (TG \> 3 mmol/L and/or tot. chol. \> 8 mmol/L)
* Corn products prior to treatment (≤ 48 hour)
* Presence of gallbladder stones.
* Known allergy for cow milk and/or lactose intolerance
18 Years
55 Years
MALE
Yes
Sponsors
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Unilever R&D
INDUSTRY
Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ad Masclee, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Maastrich University Medical Center
Locations
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Maastricht University Medical Center
Maastricht, Limburg, Netherlands
Countries
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References
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Keszthelyi D, Knol D, Troost FJ, van Avesaat M, Foltz M, Masclee AA. Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol-containing yoghurt drink. Eur J Nutr. 2013 Jun;52(4):1417-20. doi: 10.1007/s00394-012-0440-3. Epub 2012 Aug 23.
Other Identifiers
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MEC 09-2-042
Identifier Type: -
Identifier Source: org_study_id