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Vitamin K-absorption From Dairy

NCT ID: NCT00931437

Last Updated: 2010-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2009-11-30

Brief Summary

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Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.

Detailed Description

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Conditions

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Healthy

Keywords

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vitamin K Bio-availability

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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vitamin K-rich dairy product

one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.

Group Type EXPERIMENTAL

vitamin K-rich dairy product

Intervention Type DIETARY_SUPPLEMENT

several forms of vitamin K: phylloquinone, menaquinone-7,-8,-9,and -10.

Interventions

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vitamin K-rich dairy product

several forms of vitamin K: phylloquinone, menaquinone-7,-8,-9,and -10.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women between 20 and 45 years old
* Subjects of normal body weight and height according to BMI \< 30
* Subjects of Caucasian race
* Subject has given written consent to take part in the study

Exclusion Criteria

* Subjects with (a history of) metabolic or gastrointestinal disease
* Subjects presenting chronic degenerative and/or inflammatory disease
* Abuse of drugs and/or alcohol
* Subjects receiving corticoid treatment
* Subjects using oral anticoagulants
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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VitaK BV

Principal Investigators

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Cees Vermeer, PhD

Role: PRINCIPAL_INVESTIGATOR

VitaK / University of Maastricht

Locations

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VitaK BV / University of Maastricht

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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08-3-086

Identifier Type: -

Identifier Source: org_study_id